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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by jaby on July 28, 2003, at 18:13:25
I am taking my first TCA (desipramine) after completing over 25 trials on other meds. It has worked okay, but I am taking a low dose and about 1:00 everyday I get headaches, stomach pain, depression, derealization, etc. It's like clockwork. I'm trying to figure out if I need to ditch the med or up the dose (which is very small). Could I be going through a little mini withdrawl each afternoon? Any similar experiences?
Posted by Jasmine Neroli on July 28, 2003, at 18:56:57
In reply to Daily withdrawl possible???, posted by jaby on July 28, 2003, at 18:13:25
Hmmm...funny you should pose that question. I was just wondering the same thing, cuz about 3 hours or so before my next dose of Remeron, I get a passing, spacey derealization feeling (or a bit of dizziness), lethargy and the occasional headache. As you say, like clockwork. Anybody out there with any theories???? Dr. Bob?
Posted by stjames on July 29, 2003, at 1:28:38
In reply to Daily withdrawl possible???, posted by jaby on July 28, 2003, at 18:13:25
I'm trying to figure out if I need to ditch the med or up the dose (which is very small). Could I be going through a little mini withdrawl each afternoon? Any similar experiences?
This should not happen, as TCA's have quite long half lives. desipramine is 21 hours. After a week or so on a TCA you generally reach a steady state level
of the TCA or assoc. actives.
Posted by SLS on July 29, 2003, at 6:16:29
In reply to Daily withdrawl possible???, posted by jaby on July 28, 2003, at 18:13:25
> I am taking my first TCA (desipramine) after completing over 25 trials on other meds. It has worked okay, but I am taking a low dose and about 1:00 everyday I get headaches, stomach pain, depression, derealization, etc. It's like clockwork. I'm trying to figure out if I need to ditch the med or up the dose (which is very small). Could I be going through a little mini withdrawl each afternoon? Any similar experiences?
I need to take 300mg of imipramine or desipramine in order to benefit from it. I find that if I miss a dose, I begin to relapse within 12 hours. Also, I recapture the improvement within 15-30 minutes after taking an adequate dose. To answer your question, I think it is quite possible that you are gaining and then losing an improvement that desipramine might be providing you. I think it makes sense to push the dosage.
Good luck.
- Scott
This is the end of the thread.
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