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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Jack Smith on January 27, 2003, at 16:34:53
I am seriously considering going on an MAOI for my anxiety/depression. I am having moderate success on an ssri/WB combo but from all the good things I have heard about the MAOI's and from the symptomology I have which seems like atypical depression, it seems like an MAOI might give me the "breakthrough" I have been looking for for a long time.
I am just curious why so many people seem to prefer Nardil to Parnate. Parnate's side effect profile seems so much better, less sexual sides and less weight gain. Any insights from Nardil or Parnate users. Any help appreciated.
Jack
Posted by ace on January 27, 2003, at 21:51:24
In reply to Nardil or Parnate??, posted by Jack Smith on January 27, 2003, at 16:34:53
> I am seriously considering going on an MAOI for my anxiety/depression. I am having moderate success on an ssri/WB combo but from all the good things I have heard about the MAOI's and from the symptomology I have which seems like atypical depression, it seems like an MAOI might give me the "breakthrough" I have been looking for for a long time.
>
> I am just curious why so many people seem to prefer Nardil to Parnate. Parnate's side effect profile seems so much better, less sexual sides and less weight gain. Any insights from Nardil or Parnate users. Any help appreciated.
>
> JackMost people who prefer Nardil have a serious anxiety component to their illness. At higher doses Nardil works on GABA. I don't believe Parnate does. However, I have definately heard of people who prefered Parnate over Nardil, even those with strong anxiety. It's true, Parnate has much less s/e's. If your prob is more depression try Parnate first. If more anxiety, try Nardil. Both are very good. Search old threds and you'll find a lot of Parnate fans.
Posted by ZeeZee on January 28, 2003, at 10:24:44
In reply to Re: Nardil or Parnate?? » Jack Smith, posted by ace on January 27, 2003, at 21:51:24
My only dx is panic disorder and agoraphobia, no depression. I began on Nadil which was miraculous in its effect to reduce both the panc/anxiety and phobic response. I switched to Parnate due the the numerous and annoying side effects. Not only did I receive the same miraculous response for my anxiety symptoms, the side effects were "pleasant" i.e., inceased energy, increased libido, and mildly decreased appetite with concurrent weight loss.
I disagree that Nardil is better for anxiety and Parnate for depression. Parnate is more energizing and takes a while to get used to. A slow progression of dose so the body can adjust will help with that. I NEVER experienced an increase in anxiety and panic as I have on SSRI's and SNRI's (a typical s/e) I never took more than 50mgs. and was on it for over 4 years.
I only wish I never stopped.
Posted by Jack Smith on January 28, 2003, at 11:50:33
In reply to Not for me! » ace, posted by ZeeZee on January 28, 2003, at 10:24:44
Are you back on parnate now?
I have a big anxiety component to my depression but when I start ssri's my anxiety increases but it doesn't really bother me because I know it will settle down and it is just drug induced.
Posted by Jack Smith on January 28, 2003, at 11:51:59
In reply to Re: Nardil or Parnate?? » Jack Smith, posted by ace on January 27, 2003, at 21:51:24
> At higher doses Nardil works on GABA. I don't believe Parnate does.Pardon my ignorance but what is GABA?
Posted by ZeeZee on January 28, 2003, at 11:56:41
In reply to Re: Not for me--zee zee, posted by Jack Smith on January 28, 2003, at 11:50:33
Unfortunately no. I tried it again this summer after 4 years (and no return of symptoms until the last 6 mos) and had some weird atypical s/e's that wouldn't allow me to continue. I can't find a pdoc in my area who will use MAOI's. I have one now that I like and hoped to be put on Moclobemide but she refused and I am now on day 8 of .5mgs of Paxil (and fearful). Hopefully I will continue to tolerate it and get up to a therapeutic dose and have positive results.
Good luck to you.
Posted by ace on January 28, 2003, at 20:22:14
In reply to Re: Nardil or Parnate??--GABA?, posted by Jack Smith on January 28, 2003, at 11:51:59
>
> > At higher doses Nardil works on GABA. I don't believe Parnate does.
>
> Pardon my ignorance but what is GABA?
>
>GABA is a neurotransmitter, like serotonin, dopamine etc. It is by far the most predominate inhibitory NT in the brain. It is our natural 'calmer'. Benzodiazepams, like Valium, work on GABA, to reduce anxiety, produce calm, and induce sleep.
Posted by djmmm on January 29, 2003, at 9:18:38
In reply to Re: Nardil or Parnate??--GABA? » Jack Smith, posted by ace on January 28, 2003, at 20:22:14
true..but Nardil does effect GABA at ANY dose. It's due to one of its metabolites.
This is the end of the thread.
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