Psycho-Babble Medication Thread 130634

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Please help--question about correct dosage

Posted by Dreamerz on December 5, 2002, at 10:42:36


My doctor in uk has no experience with treating mood disorders with the new anti-convulsants..
I currently take Depakote(controlled release) and Neurontin.

I take the depakote 3 times a day and the neurontin just twice a day..
I think my doc has got the dosage the wrong way round.
Should the neurontin be 3 times a day and depakote just twice?
Also after I explained to him that the Neurontin starts to leave the body after about 5 hours --he still insisted on having a blood test to see the level of it in my blood
Sorry if my post is scatterbrained

Thanks.

 

Re: Please help--question about correct dosage

Posted by Larry Hoover on December 5, 2002, at 10:56:02

In reply to Please help--question about correct dosage, posted by Dreamerz on December 5, 2002, at 10:42:36

>
> My doctor in uk has no experience with treating mood disorders with the new anti-convulsants..
> I currently take Depakote(controlled release) and Neurontin.
>
> I take the depakote 3 times a day and the neurontin just twice a day..
> I think my doc has got the dosage the wrong way round.
> Should the neurontin be 3 times a day and depakote just twice?
> Also after I explained to him that the Neurontin starts to leave the body after about 5 hours --he still insisted on having a blood test to see the level of it in my blood
> Sorry if my post is scatterbrained
>
> Thanks.

Gabapentin (Neurontin) has a shorter half-life than valproate (Depakote). The most common recommendation for gabapentin is thrice daily, but some even recommend four times a day dosing, where an individual exhibits loss of efficacy between doses. Gabapentin is absorbed via an amino-acid pump called the LNAA transporter. There is a limit to how much you can absorb at one time, and food affects that as well. Kidney clearance determines the blood half-life. Do you need references?

http://www.medscape.com/viewarticle/417970


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