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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by VK on October 18, 2002, at 17:36:45
I have just been prescribed low doses of Risperdal and Prozac. I came home and did a little research, and it seems that Risperdal works in part by reducing the activity of serotonin. Prozac works by preventing the re-uptake of serotonin (i.e., increasing the activity of serotonin?).
Would the effect on serotonin of these two medications cancel each other out?
Anyone have any experience with using these meds concurrently?
Posted by BrittPark on October 18, 2002, at 21:05:54
In reply to Risperdal, Prozac, and serotonin?, posted by VK on October 18, 2002, at 17:36:45
Risperdal is a 5HT2a antagonist and prozac is a serotonin reuptake inhibitor. No one knows how antidepressants actually work, but one theory is that SSRIs cause a down-regulation of postsynaptic serotonin receptors. Since risperdal inhibits a particular serotonin receptor it's quite possible that its action is synergistic with prozac, only faster acting. Whatever the biochemistry, the combination of an atypical AP and an AD is very common in treating depression. So don't worry about the combo.
Feel Better,
Britt
Posted by VK on October 18, 2002, at 21:17:40
In reply to Re: Risperdal, Prozac, and serotonin? » VK, posted by BrittPark on October 18, 2002, at 21:05:54
thank you, I feel reassured!
Posted by henryO on October 20, 2002, at 5:30:47
In reply to Re: Risperdal, Prozac, and serotonin? » BrittPark, posted by VK on October 18, 2002, at 21:17:40
I take the two together and find that Resperdal has an augmenting effect on the Prozac. Somedays are better than others.
Posted by VK on October 21, 2002, at 0:32:24
In reply to Re: Risperdal, Prozac, and serotonin?, posted by henryO on October 20, 2002, at 5:30:47
Thanks for the info.
This is the end of the thread.
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