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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Jason911 on February 26, 2002, at 12:59:32
I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
Posted by Elizabeth on February 28, 2002, at 2:19:27
In reply to HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Jason911 on February 26, 2002, at 12:59:32
> I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
I actually got up to 40 mg, I think, but I was on 10 mg for a while. I did not find it helpful in that regard, alas.
-e
Posted by Jason911 on February 28, 2002, at 13:45:12
In reply to Re: HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Elizabeth on February 28, 2002, at 2:19:27
Thanks for your response! But as for the libido... you're a woman and that opinion doesn't relate to me that much :) Did you find it helpful in ANY way? -Jason911
>
> I actually got up to 40 mg, I think, but I was on 10 mg for a while. I did not find it helpful in that regard, alas.
>
> -e
Posted by JohnX2 on February 28, 2002, at 14:59:34
In reply to HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Jason911 on February 26, 2002, at 12:59:32
Jason,A wizard of dopaminergic medicines on psychobabble
was AndrewB. No one will deny this. He is an extremely learned and
intelligent individual. He hasn't been posting much on this news
group lately.He is really smart and believed strongly in going straight
after dopamine as a depression treatment. He researched thoroughly
most of the dopaminergic medicines and tested a lot of them himself.Anyways, if you want to look into dopamine, I would dig through
old pbabble posts for AndrewB posts.He was really hot for a medicine called amisulpride which blocked
the dopamine autoreceptor.The latest cocktail he was on included (I don't remember the doses):
amisulpride
adderall
memantine
klonopin
selegilineThe selegiline was low dose from what I remembered primarily for
neuroprotective properties. He also experienced poop out issues
with Adderral, and the memantine medication alleviated the tolerance
issue to Adderall. He also believed that memantine could prevent
risk of tardive dyskinesia from amisulpride.-John
> I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
Posted by Elizabeth on February 28, 2002, at 16:53:41
In reply to Re: HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX? » Elizabeth, posted by Jason911 on February 28, 2002, at 13:45:12
> Thanks for your response! But as for the libido... you're a woman and that opinion doesn't relate to me that much :)
Actually, drugs that affect sex drive tend to have similar effects for men and women (that is, if a drug improves women's sex drive, it will probably do the same for men). Of course, I'm just one data point, so my response doesn't mean too much. It seems likely that my sex drive would have increased if selegiline had improved my mood (I find the idea of wanting sex while depressed utterly baffling).
Anyway, this is the internet -- I could easily be a guy. <g>
> Did you find it helpful in ANY way?
No. I found it unpleasant and jittery.
-elizabeth
Posted by Jason911 on February 28, 2002, at 21:18:57
In reply to old pbabble posts for dopaminergic meds. » Jason911, posted by JohnX2 on February 28, 2002, at 14:59:34
Thank you very much for your posts. Indeed I HAVE read alot of posts by Andrew and wondered myself why he hasn't posted lately. I guess he found a group of meds that have worked and hasn't needed to come back to post very much as he could be now "cured". I don't know, but I too believe (like I said before) that 60% or more of depressed people are so because of dopamine related problems and not serotonin like people tend to believe now. The SSRI's just mask the depressed individual who's problem is dopamine. Like a safety net. Alot of recreational drugs have a dramatic effect on serotonin and the SSRI's sort of give those people that buzz and slight mood lift but don't cure the people depression completely in my mind. It just makes their lives managable for once in their life. But don't get me wrong, there are people who do have serotonin related depression and the SSRI's have worked wonders in those people (although some are affected by those dreaded side-effects, but I guess feeling better outweights a side-effect or 2 or 3 or 4) Memantine isn't available anymore (I would have used it along time ago if this weren't the case) like I said in my precvious posts as well as amineptine, which was another great dep-med for dopamine-related depression. But I guess those meds worked so well that they took them off the market. Damned those FDA pricks. They are denying us our potential "cures", ya know? I will look into amisulpride but I don't think that is even available anymore. Thanks for your comments. And how do I search for past posters like Andrew B. I know how to search for names like selegiline+klonopin, but how to I search for specific posters??? I need a cure for my dopamine-related depression!!!! My Jumex comes in about 2 and a half weeks and I'll let everyone know how that goes with the Klonopin. I'm off the Wellbutrin because it didin't do anything mood-wise and just increased my anxiety. Since being off the bupropion, my optimal dosage of Klonopin is 3mg/day. I feel great and relaxed and anxiety free now!!! That's one step. The next is relieveing the slight mental fog that is created (which I believe the Jumex will help) and I still have trouble effeciently concentrating. JohnX, you're a cool guy. Keep me up to date... -Jason911
>
> Jason,
>
> A wizard of dopaminergic medicines on psychobabble
> was AndrewB. No one will deny this. He is an extremely learned and
> intelligent individual. He hasn't been posting much on this news
> group lately.
>
> He is really smart and believed strongly in going straight
> after dopamine as a depression treatment. He researched thoroughly
> most of the dopaminergic medicines and tested a lot of them himself.
>
> Anyways, if you want to look into dopamine, I would dig through
> old pbabble posts for AndrewB posts.
>
> He was really hot for a medicine called amisulpride which blocked
> the dopamine autoreceptor.
>
> The latest cocktail he was on included (I don't remember the doses):
>
> amisulpride
> adderall
> memantine
> klonopin
> selegiline
>
> The selegiline was low dose from what I remembered primarily for
> neuroprotective properties. He also experienced poop out issues
> with Adderral, and the memantine medication alleviated the tolerance
> issue to Adderall. He also believed that memantine could prevent
> risk of tardive dyskinesia from amisulpride.
>
> -John
>
>
>
> > I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
Posted by Jason911 on February 28, 2002, at 21:53:13
In reply to Re: HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Elizabeth on February 28, 2002, at 16:53:41
Wanting sex while having a depressed mood relates to a lack of PEA. I would say try to the Jumex again, but only at 2.5 or 5mg. If you find splitting a pil a real pain, try taking 5mg every other day. I really think it could work for you. Also, you could give Concerta a try! -Jason911
(I find the idea of wanting sex while depressed utterly baffling).
>
> Anyway, this is the internet -- I could easily be a guy. <g>
>
> > Did you find it helpful in ANY way?
>
> No. I found it unpleasant and jittery.
>
> -elizabeth
Posted by JohnX2 on March 1, 2002, at 0:48:19
In reply to Re: old pbabble posts for dopaminergic meds. » JohnX2, posted by Jason911 on February 28, 2002, at 21:18:57
Jason,A lot of depression has to do with dysregulation of
the HPA (hypothalamus-pituitary-adrenal) axis. Generally
in chronically depressed patients there is excessive
stimulation of the HPA axis. This is thought to be caused
by downregulated glucocorticoid receptors. The adrenal glands are responsible for
indirectly regulating the production of (nor)adrenaline.
With a dysfunctional HPA axis, this system will
be dysfunctional and you can forget about getting a
robust noradrenergic/dopamine response. SSRI medications help to correct malfunctions
in the HPA axis, thus normalizing the noradrenaline and
dopaminergic systems also. Norepinpherine reuptake
inhibitors can do this too in different ways. Same for
healthy MAOI doses. So its really not all that
simple to discount one system vs. another. But it takes
time and a healthy dose for an anti-depressant to cause
this cascade of biological changes to take place.
For example, I find it odd that you do not get a response to amphetamines.
This could point to a dysruption in your HPA axis, who knows.Btw, what are your symptoms? Major Depression,
Dysthymia, bipolar, etc?A good website to understand these interactions is:
http://www.acnp.org/g4/
> Thank you very much for your posts. Indeed I HAVE read alot of posts by Andrew and wondered myself why he hasn't posted lately. I guess he found a group of meds that have worked and hasn't needed to come back to post very much as he could be now "cured". I don't know, but I too believe (like I said before) that 60% or more of depressed people are so because of dopamine related problems and not serotonin like people tend to believe now. The SSRI's just mask the depressed individual who's problem is dopamine. Like a safety net. Alot of recreational drugs have a dramatic effect on serotonin and the SSRI's sort of give those people that buzz and slight mood lift but don't cure the people depression completely in my mind. It just makes their lives managable for once in their life. But don't get me wrong, there are people who do have serotonin related depression and the SSRI's have worked wonders in those people (although some are affected by those dreaded side-effects, but I guess feeling better outweights a side-effect or 2 or 3 or 4) Memantine isn't available anymore (I would have used it along time ago if this weren't the case) like I said in my precvious posts as well as amineptine, which was another great dep-med for dopamine-related depression. But I guess those meds worked so well that they took them off the market. Damned those FDA pricks. They are denying us our potential "cures", ya know? I will look into amisulpride but I don't think that is even available anymore. Thanks for your comments. And how do I search for past posters like Andrew B. I know how to search for names like selegiline+klonopin, but how to I search for specific posters??? I need a cure for my dopamine-related depression!!!! My Jumex comes in about 2 and a half weeks and I'll let everyone know how that goes with the Klonopin. I'm off the Wellbutrin because it didin't do anything mood-wise and just increased my anxiety. Since being off the bupropion, my optimal dosage of Klonopin is 3mg/day. I feel great and relaxed and anxiety free now!!! That's one step. The next is relieveing the slight mental fog that is created (which I believe the Jumex will help) and I still have trouble effeciently concentrating. JohnX, you're a cool guy. Keep me up to date... -Jason911
>
>
>
> >
> > Jason,
> >
> > A wizard of dopaminergic medicines on psychobabble
> > was AndrewB. No one will deny this. He is an extremely learned and
> > intelligent individual. He hasn't been posting much on this news
> > group lately.
> >
> > He is really smart and believed strongly in going straight
> > after dopamine as a depression treatment. He researched thoroughly
> > most of the dopaminergic medicines and tested a lot of them himself.
> >
> > Anyways, if you want to look into dopamine, I would dig through
> > old pbabble posts for AndrewB posts.
> >
> > He was really hot for a medicine called amisulpride which blocked
> > the dopamine autoreceptor.
> >
> > The latest cocktail he was on included (I don't remember the doses):
> >
> > amisulpride
> > adderall
> > memantine
> > klonopin
> > selegiline
> >
> > The selegiline was low dose from what I remembered primarily for
> > neuroprotective properties. He also experienced poop out issues
> > with Adderral, and the memantine medication alleviated the tolerance
> > issue to Adderall. He also believed that memantine could prevent
> > risk of tardive dyskinesia from amisulpride.
> >
> > -John
> >
> >
> >
> > > I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
Posted by Jason911 on March 1, 2002, at 10:52:54
In reply to Re: old pbabble posts for dopaminergic meds. » Jason911, posted by JohnX2 on March 1, 2002, at 0:48:19
I have really no classification to my depression and my pdoc hasn't told me anything about my classification either. I would have to say I'm atypical to say the least. And the fact that I don't respond to amphetamines is really odd I think too, (regarding Adderall - no response at even 50mg at once). But, on the other hand, Ritalin did have a major impact on me when I took a single dose from my sisters med supply. It made me quite hyper and I would couldn't keep still and I acted like a frickin ADHD prototype. So, anyway, I was thining that the Jumex would help with my depression along with the Klonopin to increase my catacholamine activity as well as PEA for a good mood brightener. Low-dose only though. Like eventually 5mg every other day or so with supplementaion of the precurser to PEA, phenylalanine. It should at least releave the mental fog caused by the Klonopin. My anxiety is gone with it and I feel so much better now that THAT has been taken care of. I don't think my depression has anything to do with serotonin. In the past I'd take up to 900mg/day on the 5-HTP and didn't experience hardly anything. My symptoms are low-motivation, anxiety (which is now fixed with the Klonopoin), lack of desire, etc. But I don't feel sad or suicidal or anything. And so therefore the SSRI's are out of the question, I don't want any of those pesky sexual side-effects, especially at 17. MAO-B inhibition just might do it for me. Like I said before people have posted saying that the Klonopin+low-dose selegiline cured their depression and anxiety and that they seemed to benefit from eachother. Increased motivation, sex-drive, anxiety gone, and feeling awesome! I hope that this would work for me. What meds would you suggest for me other than the plan that I have come up with, which really won't be put to the test until my Jumex arrives in 2.5 weeks. -Jason911
Posted by JohnX2 on March 1, 2002, at 22:24:50
In reply to Re: old pbabble posts for dopaminergic meds. » JohnX2, posted by Jason911 on March 1, 2002, at 10:52:54
Good luck with the Jumex. Wellbutrin, Parnate, high dose Deprynyl,
possibly Lamictal, NRI tricyclics, Reboxetine, Mirapex, ..Bromocriptine,
Adderall, Dexedrine, Modafinil, Cylert, Ritalin, all may be helpful with anergic depression. 5-htp is a total joke (except for insomnia treatment),
I wouldn't use it as a proxy for what an SSRI would do. A lot of people find Zoloft,Prozac, and
Effexor quite energizing. Medicines that block the serotonin 5ht-2 receptors help to
overcome the sexual dysfunctions induced by SSRIs.I'm *VERY* glad you are not suffering from a Major Depression.
Good luck.
-John
> I have really no classification to my depression and my pdoc hasn't told me anything about my classification either. I would have to say I'm atypical to say the least. And the fact that I don't respond to amphetamines is really odd I think too, (regarding Adderall - no response at even 50mg at once). But, on the other hand, Ritalin did have a major impact on me when I took a single dose from my sisters med supply. It made me quite hyper and I would couldn't keep still and I acted like a frickin ADHD prototype. So, anyway, I was thining that the Jumex would help with my depression along with the Klonopin to increase my catacholamine activity as well as PEA for a good mood brightener. Low-dose only though. Like eventually 5mg every other day or so with supplementaion of the precurser to PEA, phenylalanine. It should at least releave the mental fog caused by the Klonopin. My anxiety is gone with it and I feel so much better now that THAT has been taken care of. I don't think my depression has anything to do with serotonin. In the past I'd take up to 900mg/day on the 5-HTP and didn't experience hardly anything. My symptoms are low-motivation, anxiety (which is now fixed with the Klonopoin), lack of desire, etc. But I don't feel sad or suicidal or anything. And so therefore the SSRI's are out of the question, I don't want any of those pesky sexual side-effects, especially at 17. MAO-B inhibition just might do it for me. Like I said before people have posted saying that the Klonopin+low-dose selegiline cured their depression and anxiety and that they seemed to benefit from eachother. Increased motivation, sex-drive, anxiety gone, and feeling awesome! I hope that this would work for me. What meds would you suggest for me other than the plan that I have come up with, which really won't be put to the test until my Jumex arrives in 2.5 weeks. -Jason911
Posted by Rocket_Boy on March 1, 2002, at 22:46:16
In reply to Re: old pbabble posts for dopaminergic meds. » Jason911, posted by JohnX2 on March 1, 2002, at 22:24:50
Jason,
I think I have the same thing going on as you do. I dont have major depression but just lack the drive and energy to enjoy life anymore and it's pissing me off. I am really interested to see how the deprenyl does for you. I am a diabetic and Im sure that makes matters worse for me. I'm waiting for the adrafinil to take effect, second day so far. It sucks your only 17 and going through this. (Im 33 myself) And I agreee with you about John, it has been very helpful reading his posts and everyone elses. I have never had these problems before and have never taken any antidepressants although I read up on everything nutritional and chemical related just for interest. Good luck and let me know how it goes as I may just copycat your meds. :)
Allen
>
> Good luck with the Jumex. Wellbutrin, Parnate, high dose Deprynyl,
> possibly Lamictal, NRI tricyclics, Reboxetine, Mirapex, ..Bromocriptine,
> Adderall, Dexedrine, Modafinil, Cylert, Ritalin, all may be helpful with anergic depression. 5-htp is a total joke (except for insomnia treatment),
> I wouldn't use it as a proxy for what an SSRI would do. A lot of people find Zoloft,Prozac, and
> Effexor quite energizing. Medicines that block the serotonin 5ht-2 receptors help to
> overcome the sexual dysfunctions induced by SSRIs.
>
> I'm *VERY* glad you are not suffering from a Major Depression.
>
> Good luck.
>
> -John
>
>
>
>
>
> > I have really no classification to my depression and my pdoc hasn't told me anything about my classification either. I would have to say I'm atypical to say the least. And the fact that I don't respond to amphetamines is really odd I think too, (regarding Adderall - no response at even 50mg at once). But, on the other hand, Ritalin did have a major impact on me when I took a single dose from my sisters med supply. It made me quite hyper and I would couldn't keep still and I acted like a frickin ADHD prototype. So, anyway, I was thining that the Jumex would help with my depression along with the Klonopin to increase my catacholamine activity as well as PEA for a good mood brightener. Low-dose only though. Like eventually 5mg every other day or so with supplementaion of the precurser to PEA, phenylalanine. It should at least releave the mental fog caused by the Klonopin. My anxiety is gone with it and I feel so much better now that THAT has been taken care of. I don't think my depression has anything to do with serotonin. In the past I'd take up to 900mg/day on the 5-HTP and didn't experience hardly anything. My symptoms are low-motivation, anxiety (which is now fixed with the Klonopoin), lack of desire, etc. But I don't feel sad or suicidal or anything. And so therefore the SSRI's are out of the question, I don't want any of those pesky sexual side-effects, especially at 17. MAO-B inhibition just might do it for me. Like I said before people have posted saying that the Klonopin+low-dose selegiline cured their depression and anxiety and that they seemed to benefit from eachother. Increased motivation, sex-drive, anxiety gone, and feeling awesome! I hope that this would work for me. What meds would you suggest for me other than the plan that I have come up with, which really won't be put to the test until my Jumex arrives in 2.5 weeks. -Jason911
Posted by Jason911 on March 1, 2002, at 22:54:18
In reply to Re: old pbabble posts for dopaminergic meds., posted by Rocket_Boy on March 1, 2002, at 22:46:16
Let me know how the adrafinil works for you. I'm really interested. Please let me know the second you feel a change (good or bad). -Jason911
Posted by Jill K. on March 3, 2002, at 2:26:48
In reply to HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Jason911 on February 26, 2002, at 12:59:32
Dear Jason,
Have you ever consider you might be bipolar? Maybe lithium or lamictal would help you. Hope your better soon.
Jill
Posted by Zo on March 6, 2002, at 0:23:02
In reply to HAS ANYONE HAD SUCCESS ON LOW DOSE DEPRENYL/JUMEX?, posted by Jason911 on February 26, 2002, at 12:59:32
Sorry to tell you, el-deprenyl (sp?) did absolutely nothing. Zip. Nada.
But YMMV!
Zo
This is the end of the thread.
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