Psycho-Babble Medication Thread 89645

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increased saliva

Posted by Geno on January 10, 2002, at 19:23:03

Hello, is increased saliva a side effect of some medications. Im taking remeron, xanax, gabaril. Maybe this is due to increased hunger from the 5ht3 blockade?
geno

Re: increased saliva » Geno

Posted by CalvaryHill on January 10, 2002, at 20:01:22

In reply to increased saliva, posted by Geno on January 10, 2002, at 19:23:03

Maybe you can counteract that side-effect with a low dose of an anticholinergic tricyclic such as nortriptyline.

I've never known xanax or gabitril to increase hunger, unless one gets so much pleasure from daily eating as a result of the gabitril's dopaminergic mechanisms.

Hope that side-effect goes away,
CalvaryHill

Re: increased saliva

Posted by Geno on January 11, 2002, at 16:52:23

In reply to Re: increased saliva » Geno, posted by CalvaryHill on January 10, 2002, at 20:01:22

> Maybe you can counteract that side-effect with a low dose of an anticholinergic tricyclic such as nortriptyline.
>
> I've never known xanax or gabitril to increase hunger, unless one gets so much pleasure from daily eating as a result of the gabitril's dopaminergic mechanisms.
>
> Hope that side-effect goes away,
> CalvaryHill

What do you mean by gabatrils dopanergenic sights. I beleive its gaba you are speaking about.
geno

dopamine » Geno

Posted by CalvaryHill on January 11, 2002, at 20:31:25

In reply to Re: increased saliva, posted by Geno on January 11, 2002, at 16:52:23

You're right, it affects GABA mainly, but also dopamine to some extent:

Laboratory of Behavioral Pharmacology, Novo Nordisk A/S, Bagsvaerd, Denmark. "Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor." European Journal of Pharmacology. 196(3):257-66, 1991 Apr 24:

"In a manner similar to other anti-epileptic drugs, tiagabine potentiated dopaminergic function (methylphenidate-induced gnawing in mice) although it did not substitute for amphetamine in amphetamine-trained animals."

Re: increased saliva

Posted by JGalt on January 12, 2002, at 22:47:59

In reply to increased saliva, posted by Geno on January 10, 2002, at 19:23:03

Geno,

My first guess would be remeron. The reason I say this is personal experience from yohimbine, which like remeron, is an alpha-2 antagonist. If I take yohimbine, I feel like I'm going to drown in my own saliva and am very hungry most of the time (that's why I don't take it anymore). The alpha 2 antagonism causes a wide range cascade of events in the brain, acting on the serotonin, dopamine, and norepinephrine systems. I don't know which of these in particular is responsible for the salivation, though I do not suspect it to be directly related to the hunger as I usually start salivating excessively a while before I get the hunger/carb cravings on it. Also causes me to sweat some more and feel a little colder. All in all annoying.

JGalt

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