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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by petters on October 25, 2001, at 6:24:21
Hi...
Do you know something about a combo with Amantadine+ssri. I´ve heard it can enhache the effect from ssri. And relive the sexual side effect.
Sincerely
Petters
Posted by Cam W. on October 26, 2001, at 18:58:24
In reply to Amantadine add to ssri Cam, posted by petters on October 25, 2001, at 6:24:21
Petters - I have seen amantadine tried with antidepressants. Some people are still taking it, most stop. For relief of sexual dysfunction it is in the 20% effective range (as are most drugs used for SSRI-induced sexual dysfunction). - Cam
Posted by Elizabeth on October 26, 2001, at 20:09:05
In reply to Re: Amantadine add to ssri Cam » petters, posted by Cam W. on October 26, 2001, at 18:58:24
> Petters - I have seen amantadine tried with antidepressants. Some people are still taking it, most stop. For relief of sexual dysfunction it is in the 20% effective range (as are most drugs used for SSRI-induced sexual dysfunction). - Cam
How about for augmentation?
I was talking to my pdoc the other day, and I brought up the idea of trying Mirapex. He said he'd been involved in a clinical trial (presumably, as one of the researchers, not as a subject!) of pergolide and had been underwhelmed.
What do you think?
-elizabeth
Posted by SLS on October 26, 2001, at 21:39:38
In reply to Re: Amantadine add to ssri » Cam W., posted by Elizabeth on October 26, 2001, at 20:09:05
> > Petters - I have seen amantadine tried with antidepressants. Some people are still taking it, most stop. For relief of sexual dysfunction it is in the 20% effective range (as are most drugs used for SSRI-induced sexual dysfunction). - Cam
>
> How about for augmentation?
>
> I was talking to my pdoc the other day, and I brought up the idea of trying Mirapex. He said he'd been involved in a clinical trial (presumably, as one of the researchers, not as a subject!) of pergolide and had been underwhelmed.
>
> What do you think?
>
> -elizabethHi.
Just a quick note.
The mode of action of amantadine in the treatment of Parkinson's Disease is not well understood (at least, not last time I looked). It is possible that NMDA antagonism plays a more significant role than any presumed DA reuptake inhibition or increased DA synthesis or release. It seems hard to imagine, though, that it doesn't potentiate DAergic neurotransmission directly because it so readily produces stereotypy experimentally. If I can't get my hands on memantine should I intend to explore NMDA antagonism, I might try amantadine.
- Scott
Posted by Cam W. on October 26, 2001, at 21:45:00
In reply to Re: Amantadine add to ssri » Cam W., posted by Elizabeth on October 26, 2001, at 20:09:05
Elizabeth - I had heard that a couple of studies were being done with Mirapex augmentation. In theory, the principle looks good, but that is one of the problems with reductionism. - Cam
Posted by JohnX2 on October 26, 2001, at 22:20:13
In reply to Re: Amantadine add to ssri, posted by SLS on October 26, 2001, at 21:39:38
Scott,
Your case for memantine is too compelling to
give up. I'm working on my own proposal (within
all the legal limits, etc - > censorship patrol people)
I'll let you know how it goes.I'm wondering if part of the sexual side effect
benefit of amantadine is from the nmda antagonism
more so than the pro-dopaminergic.
The nmda antagonism may action at the 5ht-2a
receptor junction which is a key
implication in SSRI induced sexual dysfunction.-john.
> > > Petters - I have seen amantadine tried with antidepressants. Some people are still taking it, most stop. For relief of sexual dysfunction it is in the 20% effective range (as are most drugs used for SSRI-induced sexual dysfunction). - Cam
> >
> > How about for augmentation?
> >
> > I was talking to my pdoc the other day, and I brought up the idea of trying Mirapex. He said he'd been involved in a clinical trial (presumably, as one of the researchers, not as a subject!) of pergolide and had been underwhelmed.
> >
> > What do you think?
> >
> > -elizabeth
>
> Hi.
>
> Just a quick note.
>
> The mode of action of amantadine in the treatment of Parkinson's Disease is not well understood (at least, not last time I looked). It is possible that NMDA antagonism plays a more significant role than any presumed DA reuptake inhibition or increased DA synthesis or release. It seems hard to imagine, though, that it doesn't potentiate DAergic neurotransmission directly because it so readily produces stereotypy experimentally. If I can't get my hands on memantine should I intend to explore NMDA antagonism, I might try amantadine.
>
>
> - Scott
Posted by SLS on October 26, 2001, at 23:06:39
In reply to Re: Amantadine add to ssri » SLS, posted by JohnX2 on October 26, 2001, at 22:20:13
> I'll let you know how it goes.Thanks, John.
- Scott
Posted by JohnL on October 30, 2001, at 15:55:12
In reply to Amantadine add to ssri Cam, posted by petters on October 25, 2001, at 6:24:21
I recently gave Amantadine a try. I wasn't too impressed. More than anything else, it gave me a wicked headache. Its metabolism was strange too. It would start off giving me a boost of energy, then fade into a sleepy lethargic mode, and then come on with a second wave of energy better than the first. It did seem to make sexual desire stronger. But oh that headache.
I think Amantadine is a worthy candidate for some people. I'm giving several things some short comparison trials, and so far Amantadine was the one I liked the least. The SSRI in the mix is Prozac.
John> Hi...
>
> Do you know something about a combo with Amantadine+ssri. I´ve heard it can enhache the effect from ssri. And relive the sexual side effect.
>
> Sincerely
>
> Petters
Posted by SLS on October 30, 2001, at 21:00:24
In reply to Re: Amantadine add to ssri , posted by JohnL on October 30, 2001, at 15:55:12
> I recently gave Amantadine a try. I wasn't too impressed. More than anything else, it gave me a wicked headache. Its metabolism was strange too. It would start off giving me a boost of energy, then fade into a sleepy lethargic mode, and then come on with a second wave of energy better than the first. It did seem to make sexual desire stronger. But oh that headache.
>
> I think Amantadine is a worthy candidate for some people. I'm giving several things some short comparison trials, and so far Amantadine was the one I liked the least. The SSRI in the mix is Prozac.
> JohnI thought you were all straightened-out. What happened?
- Scott
Posted by JohnX2 on October 31, 2001, at 0:02:59
In reply to Re: Amantadine add to ssri , posted by JohnL on October 30, 2001, at 15:55:12
Hi Petters,
Can you describe the headache. Was it a throbbing
headache or more like a pressure in the head
(like allergies)?I am extremely interested in test driving memantine
(which is a derivative of amantadine.
Memantine lists pressure in the
head as a potential side effect, which is actually
what I was hoping it would alleviate. Pressure can occur
in certain cases where there is an interesting fluid
buildup. I think memantine is less of a dopaminergic
med.Thanks for any information. I would really
appreciate it.-john
> I recently gave Amantadine a try. I wasn't too impressed. More than anything else, it gave me a wicked headache. Its metabolism was strange too. It would start off giving me a boost of energy, then fade into a sleepy lethargic mode, and then come on with a second wave of energy better than the first. It did seem to make sexual desire stronger. But oh that headache.
>
> I think Amantadine is a worthy candidate for some people. I'm giving several things some short comparison trials, and so far Amantadine was the one I liked the least. The SSRI in the mix is Prozac.
> John
>
> > Hi...
> >
> > Do you know something about a combo with Amantadine+ssri. I´ve heard it can enhache the effect from ssri. And relive the sexual side effect.
> >
> > Sincerely
> >
> > Petters
This is the end of the thread.
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