Posted by JohnX2 on October 26, 2001, at 22:20:13
In reply to Re: Amantadine add to ssri, posted by SLS on October 26, 2001, at 21:39:38
Scott,
Your case for memantine is too compelling to
give up. I'm working on my own proposal (within
all the legal limits, etc - > censorship patrol people)
I'll let you know how it goes.I'm wondering if part of the sexual side effect
benefit of amantadine is from the nmda antagonism
more so than the pro-dopaminergic.
The nmda antagonism may action at the 5ht-2a
receptor junction which is a key
implication in SSRI induced sexual dysfunction.-john.
> > > Petters - I have seen amantadine tried with antidepressants. Some people are still taking it, most stop. For relief of sexual dysfunction it is in the 20% effective range (as are most drugs used for SSRI-induced sexual dysfunction). - Cam
> >
> > How about for augmentation?
> >
> > I was talking to my pdoc the other day, and I brought up the idea of trying Mirapex. He said he'd been involved in a clinical trial (presumably, as one of the researchers, not as a subject!) of pergolide and had been underwhelmed.
> >
> > What do you think?
> >
> > -elizabeth
>
> Hi.
>
> Just a quick note.
>
> The mode of action of amantadine in the treatment of Parkinson's Disease is not well understood (at least, not last time I looked). It is possible that NMDA antagonism plays a more significant role than any presumed DA reuptake inhibition or increased DA synthesis or release. It seems hard to imagine, though, that it doesn't potentiate DAergic neurotransmission directly because it so readily produces stereotypy experimentally. If I can't get my hands on memantine should I intend to explore NMDA antagonism, I might try amantadine.
>
>
> - Scott
poster:JohnX2
thread:82255
URL: http://www.dr-bob.org/babble/20011025/msgs/82413.html