Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by SalArmy4me on September 10, 2001, at 16:57:26
If I can't take it once at bedtime then I'm gonna have to stop taking it, because it puts me to sleep when I take it during the day. But it has a strong antidepressant effect though, so I'm reluctant to give it up for good. Any comments?
Posted by Cam W. on September 10, 2001, at 18:47:05
In reply to Does Anyone Take Moclobemide Once A Day?, posted by SalArmy4me on September 10, 2001, at 16:57:26
Sal - Because of it's short half-life, moclobemide needs to be take twice daily. Perhaps taking a larger dose at bedtime and a smaller dosage during the day may help. You need to keep a blood level up, if you are to guarantee protection. Even a smaller level is better than none at all.
Your body should get use to the daytime drowsiness eventually, and you can readjust to levels once your body adapts.
I hope that this is of some help. - Cam
Posted by JohnL on September 11, 2001, at 3:10:20
In reply to Re: Does Anyone Take Moclobemide Once A Day? » SalArmy4me, posted by Cam W. on September 10, 2001, at 18:47:05
Sal,
As you have probably seen in your own research, there have been studies to test whether short halflife meds can work with just once daily dosing. One example is Serzone. In all the clinical studies I have seen, once daily dosing worked the same as twice or three times a day dosing, with only insignificant differences. I have seen these clinical studies on Serzone, Effexor, and Wellbutrin. Though I haven't seen any studies on it, Ritalin might be another example. I mean, for example, for children treated for ADD or ADHD, it's fairly common for them to take a morning dose and an afternoon dose, but for anyone who has actually tried Ritalin it is obvious most of its effects peak and wear off within a couple hours. Yet people do well with it anyway even when doses are spread far apart.I have never seen such a study on Moclobemide, but regardless I think it would be safe to draw some inferences from other studies with other short halflife drugs.
Of course, the only way to tell for sure is to give it a personal trial.
I like Cam's idea of taking the majority of your dose at a time that helps you sleep, and then taking a smaller dose during the day. Since it has helped you so much, I would definitely try some dosing experiments and do everything possible to stay with it. You might find that once daily dosing will work fine.
Though you didn't mention it, I am guessing that the Adrafinil has not helped your fatigue. Of course, it's benefits accrue over weeks and months, not days, so it hasn't really been enough time. But regardless, if it is going to help you any I would think you would have felt some hint of benefit by now.
Anyway, take care, and please let us know how your dosing experiments turn out.
John
Posted by JonW on September 11, 2001, at 21:44:13
In reply to Re: Does Anyone Take Moclobemide Once A Day? Sal, posted by JohnL on September 11, 2001, at 3:10:20
> I have never seen such a study on Moclobemide, but regardless I think it would be safe to draw some inferences from other studies with other short halflife drugs.
Here's the address of one such study:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7593724&dopt=Abstract
Posted by Lorraine on September 12, 2001, at 8:54:37
In reply to Re: Does Anyone Take Moclobemide Once A Day? Sal, posted by JonW on September 11, 2001, at 21:44:13
Sal: I used to just take the am dose. I found it activating and couldn't sleep if I took a later dose. I got off it b/c it made me too aggitated. Sounds like we are reacting differently to it, huH?
Posted by SLS on September 12, 2001, at 9:01:56
In reply to Re: Does Anyone Take Moclobemide Once A Day? Sal, posted by JonW on September 11, 2001, at 21:44:13
> > I have never seen such a study on Moclobemide, but regardless I think it would be safe to draw some inferences from other studies with other short halflife drugs.
>
> Here's the address of one such study:
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7593724&dopt=Abstract
Moclobemide is sort of like an irreversible reversible. The drug enters and leaves the blood stream very quickly. The extended effects are due to how tenaciously the drug binds to its receptor on the MAO molecule.
- Scott
This is the end of the thread.
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