Posted by JohnL on September 11, 2001, at 3:10:20
In reply to Re: Does Anyone Take Moclobemide Once A Day? » SalArmy4me, posted by Cam W. on September 10, 2001, at 18:47:05
Sal,
As you have probably seen in your own research, there have been studies to test whether short halflife meds can work with just once daily dosing. One example is Serzone. In all the clinical studies I have seen, once daily dosing worked the same as twice or three times a day dosing, with only insignificant differences. I have seen these clinical studies on Serzone, Effexor, and Wellbutrin. Though I haven't seen any studies on it, Ritalin might be another example. I mean, for example, for children treated for ADD or ADHD, it's fairly common for them to take a morning dose and an afternoon dose, but for anyone who has actually tried Ritalin it is obvious most of its effects peak and wear off within a couple hours. Yet people do well with it anyway even when doses are spread far apart.I have never seen such a study on Moclobemide, but regardless I think it would be safe to draw some inferences from other studies with other short halflife drugs.
Of course, the only way to tell for sure is to give it a personal trial.
I like Cam's idea of taking the majority of your dose at a time that helps you sleep, and then taking a smaller dose during the day. Since it has helped you so much, I would definitely try some dosing experiments and do everything possible to stay with it. You might find that once daily dosing will work fine.
Though you didn't mention it, I am guessing that the Adrafinil has not helped your fatigue. Of course, it's benefits accrue over weeks and months, not days, so it hasn't really been enough time. But regardless, if it is going to help you any I would think you would have felt some hint of benefit by now.
Anyway, take care, and please let us know how your dosing experiments turn out.
John
poster:JohnL
thread:78498
URL: http://www.dr-bob.org/babble/20010907/msgs/78564.html