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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by PhoenixGirl on April 24, 2001, at 16:44:53
I've read that an increase in the activity of serotonin, from drugs like ssri's, causes a decrease in the activity of dopamine. Could someone clarify? I would like to know if this effect on dopamine is long-term, lasting even after the serotonin drug is stopped.
Posted by Mr.Scott on April 24, 2001, at 16:54:52
In reply to Serotonin increase causes dopamine decrease?, posted by PhoenixGirl on April 24, 2001, at 16:44:53
I share your concern.. Indeed SSRI's decrease DA activity by around 50% in the nigra striatal region.. This is The Parkinson's disease Area of the brain. Don't freak yourself out like I often do, but see the links below for some research into to matter. I posted the "SSRI'S AND PARKINSON's DISEAESE" thread earlier.. It hasn't gone very far though.. It is a scarry subject to touch and to my knowledge still only speculative.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9660102&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9416386&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8289580&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9723116&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9694033&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8909330&dopt=Abstract
Posted by mikes on April 30, 2001, at 17:32:47
In reply to Serotonin increase causes dopamine decrease?, posted by PhoenixGirl on April 24, 2001, at 16:44:53
I hypothesized this back when I was experimenting with 5-HTP. Taking 5-HTP seemed to decrease the high from opium tea and marijuana very noticeably.
However, zoloft doesn't seem to be affecting it as much. My guess is that it's more complicated than just a balance between the two neurotransmitters- at least for most people.
> I've read that an increase in the activity of serotonin, from drugs like ssri's, causes a decrease in the activity of dopamine. Could someone clarify? I would like to know if this effect on dopamine is long-term, lasting even after the serotonin drug is stopped.
Posted by Bill L on May 2, 2001, at 8:50:12
In reply to Re: Serotonin increase causes dopamine decrease?, posted by mikes on April 30, 2001, at 17:32:47
I really don't think that dopamine will stay low after the SSRI is discontinued.
> I hypothesized this back when I was experimenting with 5-HTP. Taking 5-HTP seemed to decrease the high from opium tea and marijuana very noticeably.
>
> However, zoloft doesn't seem to be affecting it as much. My guess is that it's more complicated than just a balance between the two neurotransmitters- at least for most people.
>
> > I've read that an increase in the activity of serotonin, from drugs like ssri's, causes a decrease in the activity of dopamine. Could someone clarify? I would like to know if this effect on dopamine is long-term, lasting even after the serotonin drug is stopped.
Posted by Mr.Scott on May 2, 2001, at 13:49:17
In reply to Re: Serotonin increase causes dopamine decrease?, posted by mikes on April 30, 2001, at 17:32:47
Yes.. I remember in college trying ectasy and it doing nothing for me. Everyone else was feeling great.. Then I learned Prozac which i was taking at the time blocked the effect.. And incidentally protects against the damage ecstacy can cause too.
This is the end of the thread.
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