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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by PhoenixGirl on February 8, 2001, at 8:59:50
This is an antinausea drug that is a serotonin antagonist, and I read in a book that it may be helpful for depression. Has anyone else heard of this? I've considered taking it for my frequent stomach aches and sexual problems, but it would be great if it worked against depression too. I can't remember the exact name of the book, but it was something like "Prozac, Luvox, Effexor, Vestra, and the New Antidepressants". It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
Posted by AndrewB on February 8, 2001, at 9:18:10
In reply to Ondansetron for depression, posted by PhoenixGirl on February 8, 2001, at 8:59:50
> This is an antinausea drug that is a serotonin antagonist, and I read in a book that it may be helpful for depression. Has anyone else heard of this? I've considered taking it for my frequent stomach aches and sexual problems, but it would be great if it worked against depression too. I can't remember the exact name of the book, but it was something like "Prozac, Luvox, Effexor, Vestra, and the New Antidepressants". It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
--------------------Ondansetron didn't check out as being useful for depression/social anxiety. It does have a mild arousal effect and I wonder if it may counteract some types of SSRI induced fatigue.
AndrewB
Posted by Sulpicia on February 8, 2001, at 20:40:56
In reply to Ondansetron for depression, posted by PhoenixGirl on February 8, 2001, at 8:59:50
> It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
I'm not familiar with ondansetron but do remember seeing it mentioned in Dr. Bob's Psychopharmacology Tips -- search perhaps?
The key here may be "possible" new ADs; my daughter was in a study that used modafinil as an add-on for the treatment of depression. The consensus of the grumblings [loud] of the study participants was that it did squat.
True, this is merely anectdotal. The manufacturer is really pushing this drug for lots of uses. It recently failed in trials for attention deficit disorder, much to the stockholders' dismay.
Perhaps the fact that ondansetron is grouped with modafinil should lead us to suspect that it's not going to be very useful?
Not a scientific conclusion but perhaps a consumer's surmise.I hope you find something that helps you.
S.
Posted by PhoenixGirl on February 9, 2001, at 10:08:08
In reply to Re: Ondansetron for depression » PhoenixGirl, posted by Sulpicia on February 8, 2001, at 20:40:56
I don't know about modafinil. In my pill book, it says that people taking modafinil may get high. Also I read a study in which modafinil was found to be an effecting AD augmenting agent.
I know less about odansetron. I know that it is a serotonin antagonist, like a lot of antipsychotics, and antipsychotics can sometimes augment ADs.> It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
>
> I'm not familiar with ondansetron but do remember seeing it mentioned in Dr. Bob's Psychopharmacology Tips -- search perhaps?
> The key here may be "possible" new ADs; my daughter was in a study that used modafinil as an add-on for the treatment of depression. The consensus of the grumblings [loud] of the study participants was that it did squat.
> True, this is merely anectdotal. The manufacturer is really pushing this drug for lots of uses. It recently failed in trials for attention deficit disorder, much to the stockholders' dismay.
> Perhaps the fact that ondansetron is grouped with modafinil should lead us to suspect that it's not going to be very useful?
> Not a scientific conclusion but perhaps a consumer's surmise.
>
> I hope you find something that helps you.
> S.
Posted by SLS on February 9, 2001, at 14:14:35
In reply to Re: Ondansetron for depression, posted by PhoenixGirl on February 9, 2001, at 10:08:08
Hi.
Ondansetron does antagonize (block) a specific serotonin receptor that is different from any of the antidepressants or neuroleptic antipsychotics. While these latter drugs antagonize 5-HT2a receptors, ondansetran antagonizes 5-HT3 receptors. Reducing the activity of these serotonin neurons sometimes helps to relieve nausea and vomiting, particularly after surgery.
- Scott
> I don't know about modafinil. In my pill book, it says that people taking modafinil may get high. Also I read a study in which modafinil was found to be an effecting AD augmenting agent.
> I know less about odansetron. I know that it is a serotonin antagonist, like a lot of antipsychotics, and antipsychotics can sometimes augment ADs.
>
>
>
> > It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
> >
> > I'm not familiar with ondansetron but do remember seeing it mentioned in Dr. Bob's Psychopharmacology Tips -- search perhaps?
> > The key here may be "possible" new ADs; my daughter was in a study that used modafinil as an add-on for the treatment of depression. The consensus of the grumblings [loud] of the study participants was that it did squat.
> > True, this is merely anectdotal. The manufacturer is really pushing this drug for lots of uses. It recently failed in trials for attention deficit disorder, much to the stockholders' dismay.
> > Perhaps the fact that ondansetron is grouped with modafinil should lead us to suspect that it's not going to be very useful?
> > Not a scientific conclusion but perhaps a consumer's surmise.
> >
> > I hope you find something that helps you.
> > S.
This is the end of the thread.
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