![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by Bob on January 7, 2001, at 21:53:56
I have taken AD meds for about ten years now, and gotten more or less no where. I am writing this particular post to see if there is anybody else out there who has experienced a similar response to the meds that I've observed. For everything I've tried, what usually happens is the first few weeks/months are marked by getting used to the drug and its side effects. Provided it is a drug that will help me at all, the next few months are my "therapeutic" months where I'm getting a moderate amount of help from the drug, while at the same time, am able to put up with what the side effects are doing to me. Inevitably, the side effects eventually outweigh the diminishing benefits, and I start to taper off the drug. This is where something interesting begins to happen. When I get down to levels of med where each reduction corresponds to significant reductions in blood level, it seems that briefly, while the level is actually falling in my blood, I feel great. Almost as if my norepinephrine receptors become sensitive during this time, until suddenly the levels become depleted or "stabilized" again, at which point I feel worse than ever. This phenomenon has occurred with almost all drugs I've dabbled in which I've reached therapeutic plateaus with, including: Anafranil, Effexor, Depakote, Celexa, Zoloft, etc... Of course, once blood levels actually reach zero, I experience very nasty withdrawl. Again, though, what I am wondering is whether anyone on this list ever experiences this brief period (usually a day or two) of doing well) while tapering down on meds)?
Posted by mist on January 8, 2001, at 0:19:26
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
I experienced that with St. John's Wort. The difference was not dramatic, though, but it was noticeable.
> I have taken AD meds for about ten years now, and gotten more or less no where. I am writing this particular post to see if there is anybody else out there who has experienced a similar response to the meds that I've observed. For everything I've tried, what usually happens is the first few weeks/months are marked by getting used to the drug and its side effects. Provided it is a drug that will help me at all, the next few months are my "therapeutic" months where I'm getting a moderate amount of help from the drug, while at the same time, am able to put up with what the side effects are doing to me. Inevitably, the side effects eventually outweigh the diminishing benefits, and I start to taper off the drug. This is where something interesting begins to happen. When I get down to levels of med where each reduction corresponds to significant reductions in blood level, it seems that briefly, while the level is actually falling in my blood, I feel great. Almost as if my norepinephrine receptors become sensitive during this time, until suddenly the levels become depleted or "stabilized" again, at which point I feel worse than ever. This phenomenon has occurred with almost all drugs I've dabbled in which I've reached therapeutic plateaus with, including: Anafranil, Effexor, Depakote, Celexa, Zoloft, etc... Of course, once blood levels actually reach zero, I experience very nasty withdrawl. Again, though, what I am wondering is whether anyone on this list ever experiences this brief period (usually a day or two) of doing well) while tapering down on meds)?
Posted by Peter S on January 8, 2001, at 1:50:07
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
I have noticed that a couple days to a week after I stop taking a drug that loses effectiveness I have a "rebound" effect where I feel great for a couple of days. Then it's back to normal.
The more I have experimented with different meds the more convinced I am of how little is really known about these drugs and what exactly they do and why they work (or don't). The most scientific and knowledgable sources are the ones who will admit that all the drug company sponsored studies are extremely "dirty" (non-scientific) and discussions of neurotransmitters, receptors, etc is pure speculation at this point.
> I have taken AD meds for about ten years now, and gotten more or less no where. I am writing this particular post to see if there is anybody else out there who has experienced a similar response to the meds that I've observed. For everything I've tried, what usually happens is the first few weeks/months are marked by getting used to the drug and its side effects. Provided it is a drug that will help me at all, the next few months are my "therapeutic" months where I'm getting a moderate amount of help from the drug, while at the same time, am able to put up with what the side effects are doing to me. Inevitably, the side effects eventually outweigh the diminishing benefits, and I start to taper off the drug. This is where something interesting begins to happen. When I get down to levels of med where each reduction corresponds to significant reductions in blood level, it seems that briefly, while the level is actually falling in my blood, I feel great. Almost as if my norepinephrine receptors become sensitive during this time, until suddenly the levels become depleted or "stabilized" again, at which point I feel worse than ever. This phenomenon has occurred with almost all drugs I've dabbled in which I've reached therapeutic plateaus with, including: Anafranil, Effexor, Depakote, Celexa, Zoloft, etc... Of course, once blood levels actually reach zero, I experience very nasty withdrawl. Again, though, what I am wondering is whether anyone on this list ever experiences this brief period (usually a day or two) of doing well) while tapering down on meds)?
Posted by JohnL on January 8, 2001, at 5:16:03
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
Bob,
I have experienced exactly the same thing with a lot of different drugs. Antidepressants and St Johnswort usually do it. There are some esteemed scholarly experts here who could probably explain in intricate detail why this happens. Yet I agree with a previous post that it is more speculation than fact. If we truly knew the facts, it wouldn't be such a hit-and-miss game.I have no idea what the explanations are for the experiences you've had, or I've had. I know some would say that this indicates a bipolar dysfunction, and that little bouts of hypomania are being triggered. But several popular mood stabilizers proved useless to me, so I'm not so sure about that theory. I can tell you though that my experiences were identical to yours. And I can tell you that the drugs that ended up working very well for me are Adrafinil (not Anafranil) and Amisulpride. Could there be a predictive value here? Would this mean that you too would respond to these? I don't know. But it's quite possible, especially considering the numerous drugs that have not worked well for you. That too sounds exactly like my history.
You might want to do a search on Adrafinil, and another one on Amisulpride. Try searches on several different search engines, because you'll get more information that way. For example, try Google, Alta Vista, GoTo, Excite, Yahoo, etc. There is a lot of info at one search engine that you won't find at another, and vica versa. Both drugs are easily, quickly, and legally mailordered from Europe, where they are as popular there as Prozac is here. If interested, let me know and I'll supply you with the best places to order from.
John
Posted by SLS on January 8, 2001, at 8:54:14
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
> Inevitably, the side effects eventually outweigh the diminishing benefits, and I start to taper off the drug. This is where something interesting begins to happen. When I get down to levels of med where each reduction corresponds to significant reductions in blood level, it seems that briefly, while the level is actually falling in my blood, I feel great. Almost as if my norepinephrine receptors become sensitive during this time, until suddenly the levels become depleted or "stabilized" again, at which point I feel worse than ever. This phenomenon has occurred with almost all drugs I've dabbled in which I've reached therapeutic plateaus with, including: Anafranil, Effexor, Depakote, Celexa, Zoloft, etc... Of course, once blood levels actually reach zero, I experience very nasty withdrawl. Again, though, what I am wondering is whether anyone on this list ever experiences this brief period (usually a day or two) of doing well) while tapering down on meds)?
Dear Bob,This is a well documented phenomenon. It is known as a "withdrawal positive rebound". My history has been marked by this phenomenon, particularly with tricyclics and MAO inhibitors. So much so can this positive rebound occur, that it sometimes launches someone into a mania. I have read of this happening even among people diagnosed as unipolar depressives.
I believe that all observed effects, good and bad, associated with drug treatment are significant and may offer clues as to what drugs might work. Personally, I don't know exactly what to make of this phenomenon except to suggest that MAO inhibitors, Nardil in particular, might be worth a try if you were to associate this phenomenon with a common neurophysiological substrate that we both may share. If you haven't already tried an MAOI, I would suggest it as something for you to consider. If you were to experience a partial response to one, you could then begin adding adjunctive medication such as lithium, Ritalin, or even desipramine or nortriptyline. The latter two drugs are often used in such combinations in treatment-resistant cases, and are safe to add if prudently cautious titration schedules are followed. I am currently taking Parnate + desipramine + Lamictal + Risperdal. It is helping.
- Scott
Posted by Bob on January 8, 2001, at 12:21:14
In reply to Re: response to meds in general, posted by SLS on January 8, 2001, at 8:54:14
> > Inevitably, the side effects eventually outweigh the diminishing benefits, and I start to taper off the drug. This is where something interesting begins to happen. When I get down to levels of med where each reduction corresponds to significant reductions in blood level, it seems that briefly, while the level is actually falling in my blood, I feel great. Almost as if my norepinephrine receptors become sensitive during this time, until suddenly the levels become depleted or "stabilized" again, at which point I feel worse than ever. This phenomenon has occurred with almost all drugs I've dabbled in which I've reached therapeutic plateaus with, including: Anafranil, Effexor, Depakote, Celexa, Zoloft, etc... Of course, once blood levels actually reach zero, I experience very nasty withdrawl. Again, though, what I am wondering is whether anyone on this list ever experiences this brief period (usually a day or two) of doing well) while tapering down on meds)?
>
>
> Dear Bob,
>
> This is a well documented phenomenon. It is known as a "withdrawal positive rebound". My history has been marked by this phenomenon, particularly with tricyclics and MAO inhibitors. So much so can this positive rebound occur, that it sometimes launches someone into a mania. I have read of this happening even among people diagnosed as unipolar depressives.
>
> I believe that all observed effects, good and bad, associated with drug treatment are significant and may offer clues as to what drugs might work. Personally, I don't know exactly what to make of this phenomenon except to suggest that MAO inhibitors, Nardil in particular, might be worth a try if you were to associate this phenomenon with a common neurophysiological substrate that we both may share. If you haven't already tried an MAOI, I would suggest it as something for you to consider. If you were to experience a partial response to one, you could then begin adding adjunctive medication such as lithium, Ritalin, or even desipramine or nortriptyline. The latter two drugs are often used in such combinations in treatment-resistant cases, and are safe to add if prudently cautious titration schedules are followed. I am currently taking Parnate + desipramine + Lamictal + Risperdal. It is helping.
>
>
> - ScottThanks... that was informative and helpful! I was under the impression that MAOIs had a nastier side effect profile than even the tricyclics. Do you find this to be true?
Bob
Posted by Bob on January 8, 2001, at 12:24:23
In reply to Re: response to meds in general, posted by JohnL on January 8, 2001, at 5:16:03
> Bob,
> I have experienced exactly the same thing with a lot of different drugs. Antidepressants and St Johnswort usually do it. There are some esteemed scholarly experts here who could probably explain in intricate detail why this happens. Yet I agree with a previous post that it is more speculation than fact. If we truly knew the facts, it wouldn't be such a hit-and-miss game.
>
> I have no idea what the explanations are for the experiences you've had, or I've had. I know some would say that this indicates a bipolar dysfunction, and that little bouts of hypomania are being triggered. But several popular mood stabilizers proved useless to me, so I'm not so sure about that theory. I can tell you though that my experiences were identical to yours. And I can tell you that the drugs that ended up working very well for me are Adrafinil (not Anafranil) and Amisulpride. Could there be a predictive value here? Would this mean that you too would respond to these? I don't know. But it's quite possible, especially considering the numerous drugs that have not worked well for you. That too sounds exactly like my history.
>
> You might want to do a search on Adrafinil, and another one on Amisulpride. Try searches on several different search engines, because you'll get more information that way. For example, try Google, Alta Vista, GoTo, Excite, Yahoo, etc. There is a lot of info at one search engine that you won't find at another, and vica versa. Both drugs are easily, quickly, and legally mailordered from Europe, where they are as popular there as Prozac is here. If interested, let me know and I'll supply you with the best places to order from.
> JohnJohn:
A few questions about the drugs you mention:
How long have you been taking them?
What dose levels of each have you built up to?
Are you taking anything else?
Any side effects to speak of for either one (weight gain or sexual in particular)?
How do the drugs help you, more specifically?
Any additional info would be helpful.
Thanks! Bob
Posted by SLS on January 8, 2001, at 13:14:39
In reply to Re: response to meds in general, posted by Bob on January 8, 2001, at 12:21:14
> Thanks... that was informative and helpful! I was under the impression that MAOIs had a nastier side effect profile than even the tricyclics. Do you find this to be true?
> Bob
For me, no. In fact, for me, I prefer the side effect profiles of Parnate, Nardil, and Marplan to those of both the tricyclics and SSRIs. Marplan didn't help at all, but the other two have been very helpful. I am an MAOI responder. Startup side effects can be discouraging, though:1. Low blood pressure (orthostatic hypotension): dizziness upon standing from a seated or recumbant position.
2. Inability to achieve orgasm.
3. Changes in ejaculation response.
4. Dry mouth
5. Difficulty urinating.
6. Insomnia
7. Constipation
For me, these side effects pretty much disappeared over the course of 2-4 months. If the drug works for you, I would look forward to watching these side effects disappear, with the possible exceptions of insomnia and constipation. This occurs with some people, but not with others.
I am currently taking Parnate. Right now, it is like I am taking nothing at all (except for the improvement)! Of course, everyone is different, but I have found the MAOIs to be more forgiving than either tricylics or SSRIs regarding side effects.
Drive and Orgasms: No problem.
The diet thing is generally exaggerated. There are many more foods that are safe to eat than most MAOI lists have you believe. I am not missing anything. Not even pizza (mozzarella cheese only). However, it is no less a serious matter. Eating or drinking a truly contraindicated food can lead to serious consequences, particularly dangerously high blood pressure. In the 18 years that I have been on and off MAOIs, the only instance of a food-reaction occurred when I ate 1 1/2 thin slices of pepperoni on a pizza. I ate it by mistake. I just wasn't concentrating. Still, I do not really feel deprived of food, and the list is not too hard to remember. Be aware that in the same way certain foods can cause a reaction, so too can certain drugs. These are all issues to be discussed with your doctor so that you are fully informed so as to make a decision.
Personally, I do not consider MAOIs to be a "last resort".
Bye for now.
- Scott
Posted by Bob on January 8, 2001, at 21:59:09
In reply to Re: response to meds in general » Bob, posted by SLS on January 8, 2001, at 13:14:39
> > Thanks... that was informative and helpful! I was under the impression that MAOIs had a nastier side effect profile than even the tricyclics. Do you find this to be true?
>
> > Bob
>
>
> For me, no. In fact, for me, I prefer the side effect profiles of Parnate, Nardil, and Marplan to those of both the tricyclics and SSRIs. Marplan didn't help at all, but the other two have been very helpful. I am an MAOI responder. Startup side effects can be discouraging, though:
>
> 1. Low blood pressure (orthostatic hypotension): dizziness upon standing from a seated or recumbant position.
>
> 2. Inability to achieve orgasm.
>
> 3. Changes in ejaculation response.
>
> 4. Dry mouth
>
> 5. Difficulty urinating.
>
> 6. Insomnia
>
> 7. Constipation
>
> For me, these side effects pretty much disappeared over the course of 2-4 months. If the drug works for you, I would look forward to watching these side effects disappear, with the possible exceptions of insomnia and constipation. This occurs with some people, but not with others.
>
> I am currently taking Parnate. Right now, it is like I am taking nothing at all (except for the improvement)! Of course, everyone is different, but I have found the MAOIs to be more forgiving than either tricylics or SSRIs regarding side effects.
>
> Drive and Orgasms: No problem.
>
> The diet thing is generally exaggerated. There are many more foods that are safe to eat than most MAOI lists have you believe. I am not missing anything. Not even pizza (mozzarella cheese only). However, it is no less a serious matter. Eating or drinking a truly contraindicated food can lead to serious consequences, particularly dangerously high blood pressure. In the 18 years that I have been on and off MAOIs, the only instance of a food-reaction occurred when I ate 1 1/2 thin slices of pepperoni on a pizza. I ate it by mistake. I just wasn't concentrating. Still, I do not really feel deprived of food, and the list is not too hard to remember. Be aware that in the same way certain foods can cause a reaction, so too can certain drugs. These are all issues to be discussed with your doctor so that you are fully informed so as to make a decision.
>
> Personally, I do not consider MAOIs to be a "last resort".
>
> Bye for now.
>
>
> - ScottScott:
The things I found to be intolerable about the tricyclics after awhile was the weight gain, jitteriness/yawning, and sweating. Would you say that these aren't significant problems in the long run with the MAOI's?
Did the hypotension eventually subside?
Bob
Posted by SLS on January 9, 2001, at 9:15:27
In reply to Re: response to meds in general » SLS, posted by Bob on January 8, 2001, at 21:59:09
Hi Bob,
> The things I found to be intolerable about the tricyclics after awhile was the weight gain, jitteriness/yawning, and sweating. Would you say that these aren't significant problems in the long run with the MAOI's?
I did not find either desipramine or nortriptyline to produce weight gain. I did put on quite a bit of weight with imipramine, however. I think amitriptyline (Elavil) and doxepin (Sinequan) are the worst offenders.
Of the two most effective MAO inhibitors, Parnate and Nardil, it is Nardil that most often produces weight gain. Some people gain enormous amounts of weight (perhaps more often with women) while other people like me suffer little or no weight changes at all. I think what little weight gain I experienced on Nardil involved the recovery of my sense of taste and enjoyment of food. If it weren't for the ladies, my tongue would be all but worthless while I'm depressed. I think I ate more because everything tasted so much better.
Nardil would probably be the better drug if social anxiety, social phobia, or OCD is involved. Parnate is the "cleaner" of the two with regard to side effects, and can often reduce one's appetite. Nardil is a little harder on the liver, but I don't think there is any concern with long term (decades) use if there is no existing liver pathology. Only one doctor ever thought it worth mentioning to me, as it is a non-issue.
> Did the hypotension eventually subside?
Yes. I am currently on Parnate 80mg. I have taken as much as 150mg. I have few, if any, occurrences of dizziness. Don't ask me where I get this crap from, but it was once suggested to me that MAO-inhibitors actually help to preserve one's physical youth.
No guarantees, but MAOIs are not monsters.
Let me know what you decide.
Sincerely,
Scott
Posted by Bob on January 9, 2001, at 13:49:06
In reply to Re: response to meds in general » Bob, posted by SLS on January 9, 2001, at 9:15:27
> Hi Bob,
>
> > The things I found to be intolerable about the tricyclics after awhile was the weight gain, jitteriness/yawning, and sweating. Would you say that these aren't significant problems in the long run with the MAOI's?
>
> I did not find either desipramine or nortriptyline to produce weight gain. I did put on quite a bit of weight with imipramine, however. I think amitriptyline (Elavil) and doxepin (Sinequan) are the worst offenders.
>
> Of the two most effective MAO inhibitors, Parnate and Nardil, it is Nardil that most often produces weight gain. Some people gain enormous amounts of weight (perhaps more often with women) while other people like me suffer little or no weight changes at all. I think what little weight gain I experienced on Nardil involved the recovery of my sense of taste and enjoyment of food. If it weren't for the ladies, my tongue would be all but worthless while I'm depressed. I think I ate more because everything tasted so much better.
>
> Nardil would probably be the better drug if social anxiety, social phobia, or OCD is involved. Parnate is the "cleaner" of the two with regard to side effects, and can often reduce one's appetite. Nardil is a little harder on the liver, but I don't think there is any concern with long term (decades) use if there is no existing liver pathology. Only one doctor ever thought it worth mentioning to me, as it is a non-issue.
>
> > Did the hypotension eventually subside?
>
> Yes. I am currently on Parnate 80mg. I have taken as much as 150mg. I have few, if any, occurrences of dizziness. Don't ask me where I get this crap from, but it was once suggested to me that MAO-inhibitors actually help to preserve one's physical youth.
>
> No guarantees, but MAOIs are not monsters.
>
> Let me know what you decide.
>
>
> Sincerely,
> ScottThank you for the information Scott. It was very timely and helpful. As with most of my decisions about this stuff - it goes, slow. I may not make a decision soon, but when I do, I'll let you know. One more thing: you may have mentioned this already, but how long have you been on MAOIs?
Bob
Posted by SLS on January 9, 2001, at 14:06:27
In reply to Re: response to meds in general » SLS, posted by Bob on January 9, 2001, at 13:49:06
> Thank you for the information Scott. It was very timely and helpful. As with most of my decisions about this stuff - it goes, slow. I may not make a decision soon, but when I do, I'll let you know. One more thing: you may have mentioned this already, but how long have you been on MAOIs?
>
> Bob
I have been on and off MAOIs since 1982. Mostly on. A great many people remain on an MAOI for decades. I know of no long term adverse effects. Don't trust me on that one, though. I don't have the slightest trepidation of using them for a lifetime.I'm glad you are able to take your time when making such important decisions. It sometimes takes quite a bit of time just to gather enough facts to make a good one. If you notice, since the use of MAOIs has been out of favor for at least the last 15 years, it is hard to find any current information concerning their use. There are quite a few people here who have enough experience with them to paint you a rather complete picture.
Good luck.
Sincerely,
Scott
Posted by stjames on January 9, 2001, at 15:22:30
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
I agree with SLS'es idea to try MAOI's. Another option is to try a polydrug approach. If nor-e is
what you need a good choice would be Effexor+ Remeron.James
Posted by Bob on January 10, 2001, at 10:24:11
In reply to Re: response to meds in general, posted by SLS on January 9, 2001, at 14:06:27
> > Thank you for the information Scott. It was very timely and helpful. As with most of my decisions about this stuff - it goes, slow. I may not make a decision soon, but when I do, I'll let you know. One more thing: you may have mentioned this already, but how long have you been on MAOIs?
> >
> > Bob
>
>
> I have been on and off MAOIs since 1982. Mostly on. A great many people remain on an MAOI for decades. I know of no long term adverse effects. Don't trust me on that one, though. I don't have the slightest trepidation of using them for a lifetime.
>
> I'm glad you are able to take your time when making such important decisions. It sometimes takes quite a bit of time just to gather enough facts to make a good one. If you notice, since the use of MAOIs has been out of favor for at least the last 15 years, it is hard to find any current information concerning their use. There are quite a few people here who have enough experience with them to paint you a rather complete picture.
>
> Good luck.
>
>
> Sincerely,
> Scott
Scott:What do you do about the conflict of MAOIs with so many common OTC meds like cold meds and the like. Also, what if you needed emergency surgery, what would they do about the anesthesia?
Bob
Posted by phillybob on January 10, 2001, at 10:44:24
In reply to response to meds in general, posted by Bob on January 7, 2001, at 21:53:56
Hi, Bob. I'll jump in for a moment. Back this past February, I was pretty much where you are and came to this board (you've got to go back a little distance in the archives). Anyway, I had actually been "washing out" on all ADs in preparation for the trial of an MAOI. I had come to the researched conclusion that I would likely respond to an MAOI, and the one I had chosen was to be Parnate. EVERYTHING I learned agreed with what SLS has posted here.
Anyway, I was having one of the hypomanic bounces off of the ADs, so I took a drug holiday instead and had since tooled around with other ADs, etc., to the usual avail (i.e. little to no success).
I know that an MAOI will and can always be a tried, trued and tested (for others) option for me.
However, I have since begun a new experiment which seems to be working okay so far. Please see the topiramate (Topamax) thread (above, right now) to follow the story. You should find it of interest.
Posted by Bob on January 10, 2001, at 13:16:43
In reply to (lack of) response to meds in general, posted by phillybob on January 10, 2001, at 10:44:24
> Hi, Bob. I'll jump in for a moment. Back this past February, I was pretty much where you are and came to this board (you've got to go back a little distance in the archives). Anyway, I had actually been "washing out" on all ADs in preparation for the trial of an MAOI. I had come to the researched conclusion that I would likely respond to an MAOI, and the one I had chosen was to be Parnate. EVERYTHING I learned agreed with what SLS has posted here.
>
> Anyway, I was having one of the hypomanic bounces off of the ADs, so I took a drug holiday instead and had since tooled around with other ADs, etc., to the usual avail (i.e. little to no success).
>
> I know that an MAOI will and can always be a tried, trued and tested (for others) option for me.
>
> However, I have since begun a new experiment which seems to be working okay so far. Please see the topiramate (Topamax) thread (above, right now) to follow the story. You should find it of interest.Irony of Ironies! I'm trying Topomax also! I'm taking it with Celexa right now. I've been on it for a little over two weeks. You refer to a Topomax thread, but I can't seem to find it.
Posted by phillybob on January 10, 2001, at 13:48:37
In reply to Re: (lack of) response to meds in general, posted by Bob on January 10, 2001, at 13:16:43
> Irony of Ironies! I'm trying Topomax also! I'm taking it with Celexa right now. I've been on it for a little over two weeks. You refer to a Topomax thread, but I can't seem to find it.
Well, more irony of ironies, I found the thread and here it is and you had actually already posted in it! :) http://www.dr-bob.org/babble/20001231/msgs/50878.html
Posted by SLS on January 10, 2001, at 20:53:06
In reply to Re: response to meds in general » SLS, posted by Bob on January 10, 2001, at 10:24:11
> Scott:
>
> What do you do about the conflict of MAOIs with so many common OTC meds like cold meds and the like. Also, what if you needed emergency surgery, what would they do about the anesthesia?
>
> Bob
Bob, I don't feel that I am the best qualified to answer your questions. There are several people who have a much better handle on this stuff than do I.1. Adam
2. Elizabeth S.
3. The smart lady with the beer bottle glass thing.
4. Anyone else.I should really learn more of the specific details myself. I know some, but not enough. Perhaps we should start a thread regarding contraindicated substances when taking a MAOI. In the meantime, stay away from dental anesthetics that contain epinephrine (there are preparations without it), preparations containing dextromethorphan, and Demerol.
- Scott
This is the end of the thread.
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