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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Mr. Man on November 9, 2000, at 9:12:16
I was interested in the new antidepressant reboxetine but read some people say that it caused urinary hesitancy. Sexual side effects, dry mouth, these things I am can deal with but I dont want to hurt myself on this medication from not being able to pee.
I have read many studys on reboxetine that said nothing about urinary problems but listed many other
side effects, if anyone has any experience with the drug please post it.
Posted by Sigolene on November 9, 2000, at 10:57:16
In reply to reboxetine?, posted by Mr. Man on November 9, 2000, at 9:12:16
I had a bad experience with it. Panic attacks which i never had before. couldn't sleep as well. no effect after two weeks.
Sigolene> I was interested in the new antidepressant reboxetine but read some people say that it caused urinary hesitancy. Sexual side effects, dry mouth, these things I am can deal with but I dont want to hurt myself on this medication from not being able to pee.
> I have read many studys on reboxetine that said nothing about urinary problems but listed many other
> side effects, if anyone has any experience with the drug please post it.
Posted by cole on November 9, 2000, at 14:54:12
In reply to Re: reboxetine?, posted by Sigolene on November 9, 2000, at 10:57:16
I'm a female, I had some urinary hesitancy with it-- not a whole lot. It made me alternate chills/ sweating but that diminished over time. I also slept much less on it. I had no sexual S/E but I think males may have that response more than females. My problem was that it didn't help my depression at all, actually made me worse, but I had a hard time believing it because i wanted it to work so desperately. It works for some, not for all. Try it, but be very aware of how your moods change while you take it. Good luck,
cole
Posted by JahL on November 9, 2000, at 15:28:54
In reply to reboxetine?, posted by Mr. Man on November 9, 2000, at 9:12:16
> I was interested in the new antidepressant reboxetine but read some people say that it caused urinary hesitancy. Sexual side effects, dry mouth, these things I am can deal with but I dont want to hurt myself on this medication from not being able to pee.
> I have read many studys on reboxetine that said nothing about urinary problems but listed many other
> side effects, if anyone has any experience with the drug please post it.Hi. I'm 10 days into a trial of Rebox. & find it to be remarkably free of side effects. There was a hint of urinary hesitancy on day 1 but since then I haven't been aware of any tricyclic-like effects. Today I raised the dose to 12mg/day (max dose) & feel fine, if a little edgy.
The downside? Well so far its done nothing for my depression and you've got no chance of getting it up.
Jah.
Posted by Mr. Man on November 9, 2000, at 16:31:28
In reply to Re: reboxetine?, posted by JahL on November 9, 2000, at 15:28:54
Thank you for responding to my question, and JahL
if you want to post an update on how the drug is working out for you in another 10 days or so that would be good, I have reboxetine on order and will be trying it shortly, I was on prozac for a while and it made me a little relaxed but it just wasnt even close to benifical enough for me, and i do lack motivation, energy, drive, have social problems, which i have heard reboxetine can be good at helping and the drug works on a different chemical than prozac so i am hopeful this drug will work for me, but again if anybody else has experience with this I appreciate you shareing it
Posted by JohnL on November 10, 2000, at 4:30:21
In reply to reboxetine?, posted by Mr. Man on November 9, 2000, at 9:12:16
My symptoms are very much like yours, i.e. lack of motivation, lack of energy, no fun in normal activities, etc. At one point in my treatment Reboxetine seemed like a perfect choice, especially since serotonin meds were not doing the trick and actually making my symptom cluster a little worse instead of better.
At a mere 2mg of Reboxetine I experienced a profound intensified depression, almost suicidal-like, the very first day. I stuck with it for only a few days before throwing in the towel. It was just downright scary and dangerous for me to stay in that state of mind any longer. After stopping Reboxetine, I promptly returned to my normal depressed, yet unsuicidal, self.
In my case increasing the amounts of norepinephrine was definitely the wrong thing to do. In addition to a rapid onset of severe depression, it also caused very loud tinnitus for me, in addition to the shrivelled penis condition common to elevated norepinephrine. Sex was not possible.
Many drug trials later I discovered the best cure for my anergic melancholic depressive symptoms was either Amisulpride or Adrafinil, with both together being by far the best. Unfortunately, I'm back into the sexual dysfunction thing and having to struggle to figure out what to do about that.
Anyway, some people respond very well to Reboxetine. I think it might be wise to start very low at first. Some people on the other hand to very poorly with it. I think it must have something to do with person's adrenergic pathways. Increasing norepinephrine when it isn't low to begin with is begging for trouble. But if a deficient norepinephrine ciruitry is involved, Reboxetine will likely do some good. From what I've seen at this board, people's bodies usually either dramactically embrace or dramatically reject the Reboxetine molecule.
John
Posted by SLS on November 10, 2000, at 16:22:50
In reply to Re: reboxetine?, posted by JohnL on November 10, 2000, at 4:30:21
Hi John.
> Many drug trials later I discovered the best cure for my anergic melancholic depressive symptoms was either Amisulpride or Adrafinil, with both together being by far the best. Unfortunately, I'm back into the sexual dysfunction thing and having to struggle to figure out what to do about that.
I am suspicious that dopamine D3 receptor antagonism might be the culprit. Amisulpride is a potent antagonist at this site as well as D2 receptors. Pramipexole (Mirapex) or ropinerole (Requip) might help if this is true.
I guess you have already tried Serzone. I'm not sure it would help very much if the site of action of amisulpride is in the hypothalamus.
If all else fails, you can give sulpiride a try. I have no reason for believing that it would eliminate your complaints, except perhaps that its affinity for D2 and D3 receptors is much lower than that of amisulpride. It is extrememly cheap, and has been around for a long time. It was the first neuroleptic to show a preferential binding to presynaptic autoreceptors. Sulpiride was shown to be effective for depression and dysthymia long before the appearance of amisulpride.
Post a question requesting sex info from sulpiride users.
It is available in quite a few countries. I got my supply from England under the brand name Sulpirex by Squibb. It is also sold under the name of Dogmatil.
- Scott
-------------------------------------------------------------
: J Pharmacol Exp Ther 2000 Jun;293(3):1063-73S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231
and L741,626.Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M
Department of Psychopharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France.
The selective dopamine D(3)-receptor antagonist S33084 dose dependently attenuated induction of hypothermia by 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT) and PD128,907. S33084 also dose dependently reduced 7-OH-DPAT-induced penile erections (PEs) but had little effect on 7-OH-DPAT-induced yawning and hypophagia, and it did not block contralateral rotation elicited by the preferential D(3) agonist quinpirole in unilateral substantia nigra-lesioned rats. In models of potential antipsychotic activity, S33084 had little effect on conditioned avoidance behavior and the locomotor response to amphetamine and cocaine in rats, and weakly inhibited apomorphine-induced climbing in mice. Moreover, S33084 was inactive in models of potential extrapyramidal activity in rats: induction of catalepsy and prolactin secretion and inhibition of methylphenidate-induced gnawing. Another selective D(3) antagonist, GR218,231, mimicked S33084 in inhibiting 7-OH-DPAT-induced PEs and hypothermia but neither hypophagia nor yawning behavior. Similarly, it was inactive in models of potential antipsychotic and extrapyramidal activity. In distinction to S33084 and GR218,231, the preferential D(2) antagonist L741,626 inhibited all responses elicited by 7-OH-DPAT. Furthermore, it displayed robust activity in models of antipsychotic and, at slightly higher doses, extrapyramidal activity. In summary, S33084 was inactive in models of potential antipsychotic and extrapyramidal activity and failed to modify spontaneous locomotor behavior. Furthermore, it did not affect hypophagia or yawns, but attenuated hypothermia and PEs, elicited by 7-OH-DPAT. This profile was shared by GR218,231, whereas L741,626 was effective in all models. Thus, D(2)-receptors are principally involved in these paradigms, although D(3)-receptors may contribute to induction of hypothermia and PEs. S33084 should comprise a useful tool for further exploration of the pathophysiological significance of D(3)- versus D(2)-receptors.
PMID: 10869411, UI: 20330743
Posted by Anna P. on November 14, 2000, at 14:09:32
In reply to Re: reboxetine? » JohnL, posted by SLS on November 10, 2000, at 16:22:50
> Hi John, Hi Scott
I just want to support Scott's post about Sulpiride. I didn't have sexual side effect from Sulpiride during my trial.
I have a question for Scott. Scott, do you have some info about Requip/dosage/safety? I'm affraid to try it. I have it already at home. I've responded very well before to Mirapex.
Anna P.
>
> > Many drug trials later I discovered the best cure for my anergic melancholic depressive symptoms was either Amisulpride or Adrafinil, with both together being by far the best. Unfortunately, I'm back into the sexual dysfunction thing and having to struggle to figure out what to do about that.
>
> I am suspicious that dopamine D3 receptor antagonism might be the culprit. Amisulpride is a potent antagonist at this site as well as D2 receptors. Pramipexole (Mirapex) or ropinerole (Requip) might help if this is true.
>
> I guess you have already tried Serzone. I'm not sure it would help very much if the site of action of amisulpride is in the hypothalamus.
>
> If all else fails, you can give sulpiride a try. I have no reason for believing that it would eliminate your complaints, except perhaps that its affinity for D2 and D3 receptors is much lower than that of amisulpride. It is extrememly cheap, and has been around for a long time. It was the first neuroleptic to show a preferential binding to presynaptic autoreceptors. Sulpiride was shown to be effective for depression and dysthymia long before the appearance of amisulpride.
>
> Post a question requesting sex info from sulpiride users.
>
> It is available in quite a few countries. I got my supply from England under the brand name Sulpirex by Squibb. It is also sold under the name of Dogmatil.
>
>
> - Scott
>
>
> -------------------------------------------------------------
>
>
> : J Pharmacol Exp Ther 2000 Jun;293(3):1063-73
>
> S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231
> and L741,626.
>
> Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M
>
> Department of Psychopharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France.
>
> The selective dopamine D(3)-receptor antagonist S33084 dose dependently attenuated induction of hypothermia by 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT) and PD128,907. S33084 also dose dependently reduced 7-OH-DPAT-induced penile erections (PEs) but had little effect on 7-OH-DPAT-induced yawning and hypophagia, and it did not block contralateral rotation elicited by the preferential D(3) agonist quinpirole in unilateral substantia nigra-lesioned rats. In models of potential antipsychotic activity, S33084 had little effect on conditioned avoidance behavior and the locomotor response to amphetamine and cocaine in rats, and weakly inhibited apomorphine-induced climbing in mice. Moreover, S33084 was inactive in models of potential extrapyramidal activity in rats: induction of catalepsy and prolactin secretion and inhibition of methylphenidate-induced gnawing. Another selective D(3) antagonist, GR218,231, mimicked S33084 in inhibiting 7-OH-DPAT-induced PEs and hypothermia but neither hypophagia nor yawning behavior. Similarly, it was inactive in models of potential antipsychotic and extrapyramidal activity. In distinction to S33084 and GR218,231, the preferential D(2) antagonist L741,626 inhibited all responses elicited by 7-OH-DPAT. Furthermore, it displayed robust activity in models of antipsychotic and, at slightly higher doses, extrapyramidal activity. In summary, S33084 was inactive in models of potential antipsychotic and extrapyramidal activity and failed to modify spontaneous locomotor behavior. Furthermore, it did not affect hypophagia or yawns, but attenuated hypothermia and PEs, elicited by 7-OH-DPAT. This profile was shared by GR218,231, whereas L741,626 was effective in all models. Thus, D(2)-receptors are principally involved in these paradigms, although D(3)-receptors may contribute to induction of hypothermia and PEs. S33084 should comprise a useful tool for further exploration of the pathophysiological significance of D(3)- versus D(2)-receptors.
>
> PMID: 10869411, UI: 20330743
Posted by SLS on November 14, 2000, at 15:41:04
In reply to Re: Sulpiride/JohnL/SLS, posted by Anna P. on November 14, 2000, at 14:09:32
> I have a question for Scott. Scott, do you have some info about Requip/dosage/safety? I'm affraid to try it. I have it already at home. I've responded very well before to Mirapex.
>
> Anna P.
Hi Anna.
The best person to answer your question is AndrewB. I would like to know myself. I think he has studied in detail both Mirapex and Requip. If I have time (mental energy), I will begin to look into it as both of these drugs are cadidates for my treatment.I have a few questions for you if you would be so gracious as to suffer them. :-)
- In what ways did Mirapex help you?
- What other drugs were you taking at the time?
- Why did you stop taking it? Did it "poop-out" on you?
- If it did poop-out, how long did it work for?
- If Mirapex worked so well before, why are you about to start Requip instead?
- What drugs are you on currently?
- Why does Scott ask so many questions?Thanks, Anna.
- Scott
Posted by JahL on November 15, 2000, at 17:34:41
In reply to Re: Sulpiride/JohnL/SLS, posted by Anna P. on November 14, 2000, at 14:09:32
> I have a question for Scott. Scott, do you have some info about Requip/dosage/safety? I'm affraid to try it. I have it already at home. I've responded very well before to Mirapex.
>
> Anna P.Hi Anna.
Whilst searching for the same info I came across an article that stated that 4.5mg/Pramipexole was equivalent to 15mg/Requip. What was yr effective Prami. dose? Perhaps yr correct Requip. dose would be roughly 3x that?It's only my opinion, but slow upward titration, with this figure in mind, should be safe enough.
The (supposedly eminent) pdoc I saw today warned against DA agonists(& anything non-conventional), stating that psychosis was a v real possibility. I should qualify this however, by explaining that the guy was a pr*ck. I, like y'self I imagine, will continue to experiment.
Safely.
Jah.
Posted by Anna P. on November 16, 2000, at 0:47:39
In reply to Re: Sulpiride/JohnL/SLS » Anna P., posted by SLS on November 14, 2000, at 15:41:04
> > I have a question for Scott. Scott, do you have some info about Requip/dosage/safety? I'm affraid to try it. I have it already at home. I've responded very well before to Mirapex.
> >
> > Anna P.
>
>
> Hi Anna.
>
>
> The best person to answer your question is AndrewB. I would like to know myself. I think he has studied in detail both Mirapex and Requip. If I have time (mental energy), I will begin to look into it as both of these drugs are cadidates for my treatment.
>
> I have a few questions for you if you would be so gracious as to suffer them. :-)
>
> - In what ways did Mirapex help you?
Mirapex helped with depression, gave me energy and a feeling of enjoying the life again.> - What other drugs were you taking at the time?
Moclobemide and Revia> - Why did you stop taking it? Did it "poop-out" on you?
I would never stop it if not poop-out.
> - If it did poop-out, how long did it work for?
Unfortunately about two weeks, doze increase didn't help, just put me to "square one"
> - If Mirapex worked so well before, why are you about to start Requip instead?
Because I hope maybe Requip will work longer for me (I wish)
> - What drugs are you on currently?
Reboxetine + Neurontin + Sulpiride
> - Why does Scott ask so many questions?
That's just fine Scott, we all do.
>
> Thanks, Anna.
>
Thanks Scott
>
> -
This is the end of the thread.
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