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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by SLS on July 4, 2000, at 8:46:28
Hi All.
Adrafinil does NOT act upon NE alpha-1 receptors (adrenoceptors). A friend of mine spoke to the inventor of adrafinil at a conference several years ago. The inventor stated that he was sure that it did not agonize (stimulate) NE alpha-1 receptors, and that the early work on this drug was wrong. I consider my friend to be an extremely reliable source of information.
I have not seen any evidence that either adrafinil or modafinil directly affect NE neurotransmission in any way.
Why is this important? At this point, I do not believe that inferences should be drawn as to how someone will respond to adrafinil or modafinil based upon their experiences with noradrenergic (NE) drugs and vice-versa. This would include naphazoline eye-drops.
- Scott
Posted by JohnL on July 6, 2000, at 5:32:46
In reply to Adrafinil / Modafinil and Norepinephrine (NE), posted by SLS on July 4, 2000, at 8:46:28
Scott,
I wonder why the manufacturer states in writing that Adrafinil is an alpha-1 agonist? In this day and age of political correctness, lawsuits, liabilities, and all that, a company can't just hapharzardly print something like that.
There isn't a whole lot of available research to read on Adrfinil. What there is does point to alpha-1 agonism. It's not concrete, but it does point in that direction. On the other hand, there is nothing that suggests otherwise. Except your friend. :-) Who knows, he may be right.
Not that any of it matters. If it works, cool.
JohnL
This is the end of the thread.
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