Adrafinil / Modafinil and Norepinephrine (NE)

Posted by SLS on July 4, 2000, at 8:46:28

Hi All.
Adrafinil does NOT act upon NE alpha-1 receptors (adrenoceptors). A friend of mine spoke to the inventor of adrafinil at a conference several years ago. The inventor stated that he was sure that it did not agonize (stimulate) NE alpha-1 receptors, and that the early work on this drug was wrong. I consider my friend to be an extremely reliable source of information.
I have not seen any evidence that either adrafinil or modafinil directly affect NE neurotransmission in any way.
Why is this important? At this point, I do not believe that inferences should be drawn as to how someone will respond to adrafinil or modafinil based upon their experiences with noradrenergic (NE) drugs and vice-versa. This would include naphazoline eye-drops.

- Scott

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Adrafinil / Modafinil and Norepinephrine (NE) SLS 7/4/00
Re: Adrafinil / Modafinil and Norepinephrine (NE) JohnL 7/6/00

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