![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 59 to 83 of 96. Go back in thread:
Posted by Lou Pilder on February 27, 2012, at 20:28:57
In reply to Lou's request-pheytal, posted by Lou Pilder on February 24, 2012, at 20:46:52
> > > > > > I invite any feedback from anyone who has any info about Saphris!
> > > > > >
> > > > > > Solstice
> > > >
> > > > > Solstice,
> > > > You wrote,[...I invite any feedback from anyone...].
> > > > The subject here is the use of the drug {Saphris}.
> > > > The drug has a constituant in it that was used as a gas in riot control in the 50's.
> > > > Lou
> > > >
> > > > Lou Pilder.
> > > >
> > > > You posted this statement along another thread. The original poster had asked for info about Saphris. It is my contention that you failed to do this. I don't see any information. I see words. I challenge you to prove your words. If you cannot, you might want to apologize to the person to whom you directed it for posting misinformation.
> > > >
> > > > There is so much more to this.
> > > >
> > > >
> > > > - Scott
> > > >
> > >
> > > Scott,
> > > You wrote that you think that I failed to give information concerning Saphris. The information that I gave was that Saphris has a constituant in it that was used as a gas in riot control in the 50's. You have asked me for more information concerning the words seen in that post in another thread.
> > > In order to have more information concerning the gas used in riot control in the 50's, I would like to start with Benzene.
> > > Benzene usually comes from coal tar or petroleum. You can hydroxylate benzene and get {phenol}. From phenol you can get {phenyl}.
> > > Now benzene can cause leukemia and other cancers and break chromosomes. Benzene is used in a lot of manufacturing of products including rubber, pesticides, drugs and explosives.
> > > Benzene is cancerous when breathed in the air. Benzene can also be injested and cause cancer and death. Benzene rings can be chemically coupled.
> > > Benzene was discoverd hundreds of years ago. The toxic properties and the carcinogenic properties of benzene were not proven until the early 1900's
> > > I intend to finish this unless the rule of 3 applies.
> > > Lou
> >
> > Friends,
> > What is Saphris? Where did it come from? What can it do to the one taking the drug? And other aspects.
> > Now after the riot control gas that was made in the 50's, there came a drug called Clozeril/Clozapine.
> > This drug killed many by attacking the blood to cause what is known as {agranulocytosis} which can be fatal. It also can cause diabetes, and a fatal cardic condition. There is a withdrawal from cessation which means that it could be considerd to be addictive depending on how you want to define addiction/withdrawal.
> > At any rate, the drug has many possible ways to kill the one taking it. This drug came out in the 70's.
> > Now we have {benzene} and {clozeril}. There are constituants in clozeril that are used in a gas for riot control devised in the 50's but used today in many countries.
> > Now I intend to contiue to go step by step to show what Saphris is constituted of , chemically that is. unless the rule of 3 applies.
> > Lou
>
> Friends,
> Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> Lou
> http://www.drugs.com/pro/saphris.htmlFriends,
Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}. Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
This drug has been taken off the market because of how it could cause heart disease and death. It also can cause agranulocytosis, which is a blood disease that can be fatal.
Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine. So if you read the Saphris PI there could be the disclosure of possible agranulosis. In the clinical trials, there were many deaths. Now I have not talked about the phenethylamines yet, but I meantioned them in the thread concerning Effexor. I was posted by Mr. Hsiung during that thread a prohibition that precluded me from posting a lot of information that I think, if allowed to be seen here, could save lives or prevent a life-ruining condition or addiction. I could have that same preclusion here, that might also prevent me from posting what could save lives.
So I have posted about the riot control gas, and clozaril and now Fenfluramine.
So we have seen a little about this drug called Saphhris and I intend to complete this exposition, unless the rule of three applies.
Lou
Posted by Lou Pilder on February 27, 2012, at 20:54:23
In reply to Lou's request-fenfluramine, posted by Lou Pilder on February 27, 2012, at 20:28:57
> > > > > > > I invite any feedback from anyone who has any info about Saphris!
> > > > > > >
> > > > > > > Solstice
> > > > >
> > > > > > Solstice,
> > > > > You wrote,[...I invite any feedback from anyone...].
> > > > > The subject here is the use of the drug {Saphris}.
> > > > > The drug has a constituant in it that was used as a gas in riot control in the 50's.
> > > > > Lou
> > > > >
> > > > > Lou Pilder.
> > > > >
> > > > > You posted this statement along another thread. The original poster had asked for info about Saphris. It is my contention that you failed to do this. I don't see any information. I see words. I challenge you to prove your words. If you cannot, you might want to apologize to the person to whom you directed it for posting misinformation.
> > > > >
> > > > > There is so much more to this.
> > > > >
> > > > >
> > > > > - Scott
> > > > >
> > > >
> > > > Scott,
> > > > You wrote that you think that I failed to give information concerning Saphris. The information that I gave was that Saphris has a constituant in it that was used as a gas in riot control in the 50's. You have asked me for more information concerning the words seen in that post in another thread.
> > > > In order to have more information concerning the gas used in riot control in the 50's, I would like to start with Benzene.
> > > > Benzene usually comes from coal tar or petroleum. You can hydroxylate benzene and get {phenol}. From phenol you can get {phenyl}.
> > > > Now benzene can cause leukemia and other cancers and break chromosomes. Benzene is used in a lot of manufacturing of products including rubber, pesticides, drugs and explosives.
> > > > Benzene is cancerous when breathed in the air. Benzene can also be injested and cause cancer and death. Benzene rings can be chemically coupled.
> > > > Benzene was discoverd hundreds of years ago. The toxic properties and the carcinogenic properties of benzene were not proven until the early 1900's
> > > > I intend to finish this unless the rule of 3 applies.
> > > > Lou
> > >
> > > Friends,
> > > What is Saphris? Where did it come from? What can it do to the one taking the drug? And other aspects.
> > > Now after the riot control gas that was made in the 50's, there came a drug called Clozeril/Clozapine.
> > > This drug killed many by attacking the blood to cause what is known as {agranulocytosis} which can be fatal. It also can cause diabetes, and a fatal cardic condition. There is a withdrawal from cessation which means that it could be considerd to be addictive depending on how you want to define addiction/withdrawal.
> > > At any rate, the drug has many possible ways to kill the one taking it. This drug came out in the 70's.
> > > Now we have {benzene} and {clozeril}. There are constituants in clozeril that are used in a gas for riot control devised in the 50's but used today in many countries.
> > > Now I intend to contiue to go step by step to show what Saphris is constituted of , chemically that is. unless the rule of 3 applies.
> > > Lou
> >
> > Friends,
> > Here is a link to a site that lists the effects of Saphris to the one taking he drug.I would like for interested readers to look a this in relation to adverse effects listed.
> > Lou
> > http://www.drugs.com/pro/saphris.html
>
> Friends,
> Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}. Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> This drug has been taken off the market because of how it could cause heart disease and death. It also can cause agranulocytosis, which is a blood disease that can be fatal.
> Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine. So if you read the Saphris PI there could be the disclosure of possible agranulosis. In the clinical trials, there were many deaths. Now I have not talked about the phenethylamines yet, but I meantioned them in the thread concerning Effexor. I was posted by Mr. Hsiung during that thread a prohibition that precluded me from posting a lot of information that I think, if allowed to be seen here, could save lives or prevent a life-ruining condition or addiction. I could have that same preclusion here, that might also prevent me from posting what could save lives.
> So I have posted about the riot control gas, and clozaril and now Fenfluramine.
> So we have seen a little about this drug called Saphhris and I intend to complete this exposition, unless the rule of three applies.
> LouNow the effects that saphris has on the blood is common to other drugs that have the same or similar chemical make-up. A lot of those cause agranulocytosi , such as Clozaril, and some cause a similar life-threatening condition called neutropenia, which is concerning the neutrophils in the blood. What is omprtant to the taker of these class of drugs is that {fever} can happem that is indicating this potential fatal happening of neutropenia. So a fever could warn of this condtion that could cause death.
Lou
Posted by Phillipa on February 27, 2012, at 21:16:08
In reply to Lou's request-neutropenia, posted by Lou Pilder on February 27, 2012, at 20:54:23
True about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
Posted by Solstice on February 27, 2012, at 21:41:55
In reply to Re: Lou's request-neutropenia » Lou Pilder, posted by Phillipa on February 27, 2012, at 21:16:08
> True about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
Yes, thank you for keeping the Shoppe open.Solstice
Posted by Lou Pilder on February 27, 2012, at 21:46:53
In reply to Re: Lou's request-neutropenia, posted by Solstice on February 27, 2012, at 21:41:55
> >
Phillipa and Solstice,
I need a night-watchman or night watch-woman. Could you take care of it?
LouTrue about Clozaril that I do know. Thanks for keeping the Shoppe open. Phillipa
>
>
> Yes, thank you for keeping the Shoppe open.
>
> Solstice
Posted by SLS on February 27, 2012, at 21:57:09
In reply to Lou's request-fenfluramine, posted by Lou Pilder on February 27, 2012, at 20:28:57
> Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
Okay.
> Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> This drug has been taken off the marketAlso, fenfluramine itself has been taken off of the market.
> because of how it could cause heart disease and death.
Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
Fenfluramine is a dangerous drug.
> Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
To the best of my knowledge, this is misinformation.
Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
> So if you read the Saphris PI there could be the disclosure of possible agranulosis.
To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
> In the clinical trials, there were many deaths.
To the best of my knowledge, this is misinformation.
Please provide citations for this statement.
Your use of the word "many" is an exagerration.
To the best of my knowledge the 3-post rule still applies. Life is good.
- Scott
Posted by SLS on February 27, 2012, at 22:03:40
In reply to Re: Lou's request-fenfluramine, posted by SLS on February 27, 2012, at 21:57:09
So that there be no confusion, please note that asenapine is the generic name for Saphris.
I wrote the following in my previous post:
> Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
- Scott
Posted by Lou Pilder on February 27, 2012, at 22:10:29
In reply to Re: Lou's request-fenfluramine, posted by SLS on February 27, 2012, at 21:57:09
> > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
>
> Okay.
>
> > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > This drug has been taken off the market
>
> Also, fenfluramine itself has been taken off of the market.
>
> > because of how it could cause heart disease and death.
>
> Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
>
> Fenfluramine is a dangerous drug.
>
> > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
>
> To the best of my knowledge, this is misinformation.
>
> Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
>
> > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
>
> To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
>
> Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
>
> > In the clinical trials, there were many deaths.
>
> To the best of my knowledge, this is misinformation.
>
> Please provide citations for this statement.
>
> Your use of the word "many" is an exagerration.
>
> To the best of my knowledge the 3-post rule still applies. Life is good.
>
>
> - ScottScott,
https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.html
Posted by Lou Pilder on February 27, 2012, at 22:18:00
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
> > > Now in relation to saphris, as to what the drug is and such, and what it can do to the taker of the drug, I would like to introduce in the expsition the drug known as {Fenfluramine}.
> >
> > Okay.
> >
> > > Now another drug called {phentermine} combined with (fenfluramine), gives a drug called Phen-fen.
> > > This drug has been taken off the market
> >
> > Also, fenfluramine itself has been taken off of the market.
> >
> > > because of how it could cause heart disease and death.
> >
> > Yes. Valvulopathy. Also, pulmonary hypertension if my memory serves me.
> >
> > Fenfluramine is a dangerous drug.
> >
> > > Now the drug Saphris activates in one way or another some of the same receptors as fenfluramine.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Fenfluramine is a serotonin releaser that activates many different serotonin (5-HT) receptors. Asenapine acivates only one serotonin receptor - 5-HT1a. The mechanism by which fenfluramine causes adverse heart effects is via 5-HT2b receptor activation. Saphris and fenfluramine are not alike in this respect.
> >
> > > So if you read the Saphris PI there could be the disclosure of possible agranulosis.
> >
> > To the best of my knowledge, agranulocytosis is not an adverse effect of Saphris.
> >
> > Agranulocytosis is listed on the PI only because other drugs in its class have this side effect. Can you prove that a single case of agranulocyctosis has occurred with Saphris? I couldn't find a single case on Medline/Pubmed.
> >
> > > In the clinical trials, there were many deaths.
> >
> > To the best of my knowledge, this is misinformation.
> >
> > Please provide citations for this statement.
> >
> > Your use of the word "many" is an exagerration.
> >
> > To the best of my knowledge the 3-post rule still applies. Life is good.
> >
> >
> > - Scott
>
> Scott,
> https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.htmlScott and friends,
Here is the FDA report regarding saphris. It is over 1000 pages so your system may not bring this up. It will take a long time...acrobat
Now I have highlights of the report that I will post later...
Lou
UCM173877
or
UCM123877
Posted by Solstice on February 27, 2012, at 22:26:49
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
> Scott,
> https://www.druginformer.com/search/side_effect_details/saphris/agranulocytosis.htmlInteresting... I used the "death" events filter on this site, and it came up with zero, which is far less than the "many" you reported.
Solstice
Posted by SLS on February 27, 2012, at 22:39:51
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:10:29
Not good enough.
Try again.
Or not.
There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
Do you know the difference between misinformation and disinformation? Just curious.
Please feel free to ask me any questions that you would like to have answered along this thread.
- Scottt
Posted by Phillipa on February 27, 2012, at 22:52:19
In reply to Lou's request to Phillipa and Solstice, posted by Lou Pilder on February 27, 2012, at 21:46:53
Lou I'm sorry must decline watching Shoppe at night as I think we are almost on the same time zone. So we sleep at the same time within an hour or so. So sorry. Phillipa
Posted by Lou Pilder on February 27, 2012, at 22:54:00
In reply to Re: Scott's reply-agranulocytosis » Lou Pilder, posted by SLS on February 27, 2012, at 22:39:51
> Not good enough.
>
> Try again.
>
> Or not.
>
> There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
>
> Do you know the difference between misinformation and disinformation? Just curious.
>
> Please feel free to ask me any questions that you would like to have answered along this thread.
>
>
> - ScotttScott,
Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
Lou
http://circ.ahjournals.org/content/1022/23/2836.full
Posted by Lou Pilder on February 27, 2012, at 22:57:14
In reply to Lou's reply-agranulocytosis » SLS, posted by Lou Pilder on February 27, 2012, at 22:54:00
> > Not good enough.
> >
> > Try again.
> >
> > Or not.
> >
> > There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
> >
> > Do you know the difference between misinformation and disinformation? Just curious.
> >
> > Please feel free to ask me any questions that you would like to have answered along this thread.
> >
> >
> > - Scottt
>
> Scott,
> Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> Lou
> http://circ.ahjournals.org/content/1022/23/2836.full
corrected:
http://circ.ahjournals.org/content/102/23/2836.full
Posted by Lou Pilder on February 27, 2012, at 23:02:28
In reply to correction- Lou's reply-agranulocytosis, posted by Lou Pilder on February 27, 2012, at 22:57:14
> > > Not good enough.
> > >
> > > Try again.
> > >
> > > Or not.
> > >
> > > There is only one report to the FDA according to the webpage you cited? I don't believe this website. Why should I? There is no way to verify their claims. Even if this single report exists, you really helped to make a case for the possibility that you exaggerate.
> > >
> > > Do you know the difference between misinformation and disinformation? Just curious.
> > >
> > > Please feel free to ask me any questions that you would like to have answered along this thread.
> > >
> > >
> > > - Scottt
> >
> > Scott,
> > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > Lou
> > http://circ.ahjournals.org/content/1022/23/2836.full
> corrected:
> http://circ.ahjournals.org/content/102/23/2836.fullcorrection:
http://circ.ahajournals.org/content/102/23/2836.full
Posted by Solstice on February 28, 2012, at 11:34:47
In reply to corection: correction- Lou's reply-agranulocytosis, posted by Lou Pilder on February 27, 2012, at 23:02:28
Lou -
I guess you are aware that your link's Clinical Investigation reiterates what Scott said - that since Saphris is not activating the 5-HT2b receptors, it is not implicated in agranulocytosis.
Solstice
> > > Scott,
> > > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > > Lou
> > > http://circ.ahjournals.org/content/1022/23/2836.full
> > corrected:
> > http://circ.ahjournals.org/content/102/23/2836.full
>
> correction:
> http://circ.ahajournals.org/content/102/23/2836.full
Posted by Lou Pilder on February 28, 2012, at 12:27:57
In reply to Re: corection: correction- Lou's reply-agranulocytosis » Lou Pilder, posted by Solstice on February 28, 2012, at 11:34:47
> Lou -
>
> I guess you are aware that your link's Clinical Investigation reiterates what Scott said - that since Saphris is not activating the 5-HT2b receptors, it is not implicated in agranulocytosis.
>
> Solstice
>
>
>
> > > > Scott,
> > > > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > > > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > > > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > > > Lou
> > > > http://circ.ahjournals.org/content/1022/23/2836.full
> > > corrected:
> > > http://circ.ahjournals.org/content/102/23/2836.full
> >
> > correction:
> > http://circ.ahajournals.org/content/102/23/2836.full
>
> Solstice,
In regards to accepting or not as to if one taking Saphris could get agranulocytosis or not, here is a link tthat could be helpful to accepting or not that ine could or could not get agranuloocytosis. Then we could go from there.
Lou
http://doublecheckmd.com/EffectsDetail.do?dname=167374&eid=3093
Posted by Lou Pilder on February 28, 2012, at 12:36:05
In reply to Lou's reply-agranulocytosis-cases » Solstice, posted by Lou Pilder on February 28, 2012, at 12:27:57
> > Lou -
> >
> > I guess you are aware that your link's Clinical Investigation reiterates what Scott said - that since Saphris is not activating the 5-HT2b receptors, it is not implicated in agranulocytosis.
> >
> > Solstice
> >
> >
> >
> > > > > Scott,
> > > > > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > > > > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > > > > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > > > > Lou
> > > > > http://circ.ahjournals.org/content/1022/23/2836.full
> > > > corrected:
> > > > http://circ.ahjournals.org/content/102/23/2836.full
> > >
> > > correction:
> > > http://circ.ahajournals.org/content/102/23/2836.full
> >
> > Solstice,
> In regards to accepting or not as to if one taking Saphris could get agranulocytosis or not, here is a link tthat could be helpful to accepting or not that ine could or could not get agranuloocytosis. Then we could go from there.
> Lou
> http://doublecheckmd.com/EffectsDetail.do?dname=167374&eid=3093
>
> correction:
http://doublecheckmd.com/EffectsDetail.do?dname=Saphris&sid=167374&eid=3093
Posted by Lou Pilder on February 28, 2012, at 13:51:02
In reply to correction: Lou's reply-agranulocytosis-cases, posted by Lou Pilder on February 28, 2012, at 12:36:05
> > > Lou -
> > >
> > > I guess you are aware that your link's Clinical Investigation reiterates what Scott said - that since Saphris is not activating the 5-HT2b receptors, it is not implicated in agranulocytosis.
> > >
> > > Solstice
> > >
> > >
> > >
> > > > > > Scott,
> > > > > > Saphris is a newer drug so the reports are not many yet as a drug like Prozac. Neutropenia is more eventfull than agranulocytosis, but as more time runs there could be more reports of that event.
> > > > > > Now what is the chemical concerning receptors are the matabolites. This could change things a bit...
> > > > > > Now here is a report that I think could be of help here. I have the report on deaths with saphris in the trials and will put that together later.
> > > > > > Lou
> > > > > > http://circ.ahjournals.org/content/1022/23/2836.full
> > > > > corrected:
> > > > > http://circ.ahjournals.org/content/102/23/2836.full
> > > >
> > > > correction:
> > > > http://circ.ahajournals.org/content/102/23/2836.full
> > >
> > > Solstice,
> > In regards to accepting or not as to if one taking Saphris could get agranulocytosis or not, here is a link tthat could be helpful to accepting or not that ine could or could not get agranuloocytosis. Then we could go from there.
> > Lou
> > http://doublecheckmd.com/EffectsDetail.do?dname=167374&eid=3093
> >
> > correction:
> http://doublecheckmd.com/EffectsDetail.do?dname=Saphris&sid=167374&eid=3093
>
> Solstice,
Now in relation to blood disorders that could cause death dfrom taking Saphris, as to if the cause of death is neutropenia or agranulocytosis, is an ongoing subject of research. I have shown one case of agranulocytosis and there are cases of neutropenia, that could also cause death.
Now here is a link to that Saphris has had people that take it result in death.
My original concern here was to show the chemical structure of saphris and then others could deceide if saphris is a new drug, or a knock-off of an old drug, on their own.
Now be adviced that Mr. Hsiung has posted here a prohibition to me that prohibits me from showing things from a particular era of time involving the political party then, that if the prohibition was not made to me, I think that lives could be saved because people wanting information about this drug could know what I am prohibited from posting here.
Here is a link to saphris in relation to people taking the drug having death.
Lou
http://www.ehealthme.com/ds/saphris/death
Posted by SLS on February 28, 2012, at 14:21:56
In reply to Lou's reply-agranulocytosis-death, posted by Lou Pilder on February 28, 2012, at 13:51:02
From your link:
Regarding Saphris:
(I added the asterisks for emphasis).
"Agranulocytosis (including fatal cases) has been reported with *other* agents in the class."
The only antipsychotic drug that produces agranulocytosis is clozapine (Clozaril). The entire class of drugs has earned a warning because on this one drug.
Not only is the word "death" used in your subject line an exaggeration of the sequalae of taking Saphris, but your projecting agranulocytosis from clozapine the the rest of the drugs in the class is a generalization that is not born out in fact.
Your posts, as seen here, habitually include:
1. Exaggeration
2. Over-generalizationI have demonstrated this numerous times.
In case you didn't know the difference:* Misinformation: Information that is incorrect.
* Disinformation: Misinformation that is deliberately disseminated in order to influence or confuse or to promote an agenda.
Your statements regarding agranulocytosis and Saprhis are incorrect.
- Scott
Posted by Lou Pilder on February 28, 2012, at 15:26:09
In reply to Re: Lou's reply-agranulocytosis-death » Lou Pilder, posted by SLS on February 28, 2012, at 14:21:56
scott,
This is the aspect that I am attempting to explain, in that Clozaril caused agranulocytosis and then the whole class of those type of drugs is suspect.
Now I have shown a report where one took saphris and got agranulocytosis. I did intend to show the chemical structure of saphris and let people make up their own mind if the drug could cause a blood disease, be it neutropenia or agranulocytosis. The point here is that death is possible from taking saphris and I was going to post the FDA synopsis of the deaths in the trials.
Here is the link to the post here that I posted a link where one got agranulocytosis, and one person getting it does show that it is possible and as time runs, we could see if other reports substantiate that it can happen. The drug is newer on the market so there has not been a great amount of time for reports to be cataloged. I want to post this information here that is factual concerning that there is a case of agranulocytosis from taking saphris and that neutropenia is listed in the PI as a possibility. As to if the one will be more evident going forward, there is still neutropenia listed now.
Here is the link to the post here that has the link to the report of a person with agranulocytosis while taking saphris. If one could get agranulocytosis, that is a warning as I see it for those that are considering taking the drug.
Lou
Here is a link to the post here that has the link to the report
http://www.dr-bob.org/babble/20120221/msgs/1011866.html
Posted by Lou Pilder on February 28, 2012, at 15:43:29
In reply to Lou's reply-agranulocytosis-death-report » SLS, posted by Lou Pilder on February 28, 2012, at 15:26:09
> scott,
> This is the aspect that I am attempting to explain, in that Clozaril caused agranulocytosis and then the whole class of those type of drugs is suspect.
> Now I have shown a report where one took saphris and got agranulocytosis. I did intend to show the chemical structure of saphris and let people make up their own mind if the drug could cause a blood disease, be it neutropenia or agranulocytosis. The point here is that death is possible from taking saphris and I was going to post the FDA synopsis of the deaths in the trials.
> Here is the link to the post here that I posted a link where one got agranulocytosis, and one person getting it does show that it is possible and as time runs, we could see if other reports substantiate that it can happen. The drug is newer on the market so there has not been a great amount of time for reports to be cataloged. I want to post this information here that is factual concerning that there is a case of agranulocytosis from taking saphris and that neutropenia is listed in the PI as a possibility. As to if the one will be more evident going forward, there is still neutropenia listed now.
> Here is the link to the post here that has the link to the report of a person with agranulocytosis while taking saphris. If one could get agranulocytosis, that is a warning as I see it for those that are considering taking the drug.
> Lou
> Here is a link to the post here that has the link to the report
> http://www.dr-bob.org/babble/20120221/msgs/1011866.htmlFriends,
Here is a warning from the FDA that I think if one considering taking the drug could read it, their life could be saved if they knew this information and had the situation arise to them.
The reaction from saphris could cause death.
Lou
http://www.fda.gov/Drugs/DrugSafety/ucm270243
Posted by SLS on February 28, 2012, at 15:59:24
In reply to Lou's reply-agranulocytosis-death-report » SLS, posted by Lou Pilder on February 28, 2012, at 15:26:09
> This is the aspect that I am attempting to explain, in that Clozaril caused agranulocytosis and then the whole class of those type of drugs is suspect.
On what grounds?
> Now I have shown a report where one took saphris and got agranulocytosis.
No, you haven't.
All you showed is that some private website says there was one instance reported to the FDA. No reference information was given to be able to corroborate this assertion. Medline/pubmed does not report a single case. Even if there were a single case, what does that say about the degree of danger possessed by Saphris. You have actually proven that Saphris is quite safe with respect to agranulocytosis.
Okay.
Enough about Saphris and agranulocytosis. If it occurs, you have proven that it is extremely rare.
- Scott
Posted by SLS on February 28, 2012, at 16:06:29
In reply to Lou's reply--death-report-fda, posted by Lou Pilder on February 28, 2012, at 15:43:29
> Here is a warning from the FDA that I think if one considering taking the drug could read it, their life could be saved if they knew this information and had the situation arise to them.
> The reaction from saphris could cause death.> http://www.fda.gov/Drugs/DrugSafety/ucm270243
Penicillin also produces fatal allergic reactions.
A great number of drugs do.
Where is the danger with Saphris? What is the observed rate of allergic reaction to Saphris? Is it higher than from penicillin?
- Scott
Posted by Lou Pilder on February 28, 2012, at 19:51:39
In reply to Saphris and Agranulocytosis - No risk » Lou Pilder, posted by SLS on February 28, 2012, at 15:59:24
> > This is the aspect that I am attempting to explain, in that Clozaril caused agranulocytosis and then the whole class of those type of drugs is suspect.
>
> On what grounds?
>
> > Now I have shown a report where one took saphris and got agranulocytosis.
>
> No, you haven't.
>
> All you showed is that some private website says there was one instance reported to the FDA. No reference information was given to be able to corroborate this assertion. Medline/pubmed does not report a single case. Even if there were a single case, what does that say about the degree of danger possessed by Saphris. You have actually proven that Saphris is quite safe with respect to agranulocytosis.
>
> Okay.
>
> Enough about Saphris and agranulocytosis. If it occurs, you have proven that it is extremely rare.
>
>
> - Scott
>Friends,
The issue here with saphris as to if it can cause agranulocytosis is not what I intended this thread to be about. I intended to show the chemical structure of the drug, where it came from and what it was used for and then the metamorphosis from the start to the ending up as saphris.
Now one important point is that the drug can cause blood diseases that could be fatal. The aspet of the drug causeing the type of blood disorder that Clozaril caused is mentioned as a warning in the FDA booklet for saphris as that drugs of that class could induce the same conditions. The theory is that the same catagory of drugs could cause the same things to cause death.
Now here is a link that states that saphris can cause agranulocytosis. It goes beyound that Clozaril could cause that because it is a drug like clozaril. It is in the review as you scroll down under adverse effects of saphris.
Since the drug is newer, there could be rapid ongoing changes in product liturature.
Now I intend to show the chemical structure of saphris and then one can decide if saphris is a new drug, or a new name for a knock-off of an old drug and then help people make a better decision as to take this drug or not with the information that I could give here so that lives could be saved, life ruining conditions could be avoided , addiction could be avoided, unless the rule of 3 applies.
Lou
here is the link to the review of saphris
http://www.pharmacistivist.com/2010/January_2010.shtml
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