Posted by musky on March 31, 2006, at 0:55:36
In reply to Re: remeron withdrawal, posted by SLS on March 29, 2006, at 8:49:08
> Hi Scott:
Im sorry but I disagree... If antidepressants did work,,, we wouldnt have so many people on them and so many people trying to get off with horrendous side effects and withdrawls.As for the Remeron yes I too have done my research and each drug may block at a different site(either before or after the synapse). and yes remeron is a dual action which worries me more as my experience has not been good at all with this drug as far as side effects.
It is blocking BOTH the serotonin and norepinephrine receptors in the brain.What meant to say in my earlier post was this , but meaning that the end result is still the same. The drug blocks the receptors then eventually the body responds by shutting down its receptors and then evetually these receptors are not made anymore.. A receptor on a cell is simply a protein which is now affected bythe drug.
This to me makes it very clear why we need to do more research into the neurorecptors and how they operate on a more detailed level..
I think that original studies with these drugs , which if you have done your research as you say,, show that the drug companies fund the research.there is enormous payback to market these so called wonder drugs..
What puzzles me is everyone seems to be taking them.. and if it truly is a biological disorder or whatever then we as a human race are definitely in trouble.If you look back years ago, when antidepressants didnt exist.. your suicide rates were lower..
And how come now on all the package inserts there is distinct warnings about the risk of these drugs?? Obviously some of the data from clincial trials is being released..
When you talk about biological affective disorder, I dont see how so many have this.. it seems everyone has some sort of disorder.. we tend to over diagnose what is probably normal response to our environment..
and as far as responding to one antidepressant or another, it also has been shown that in order to get a drug approved, one only has to have about a 30% improvement rate..(just a little better than placebo response).. to me this is not a true response.. Cognitivie therapy achieves a much higher response rate to depression that drug therapy and this has been documented.YOu have to remember statistics can show anything they want it the proper tests are applied(also done by the drug company).
You say that everyone is different yet they keep fiving the people the same thing over and over to fix a very complicated problem... The very fact that scientist dont know alot about the funcitoning of the brain/body in illness is the very reason they need to not be so hasty to prescribe a/d on such weak data presented to them by drug companies.. Doctors are pressured to do this and in todays quick fix society, its much easier to pop a pill than to get to the ROOT of the problem..
If these drugs help people,, then why are there so many sites such as these that are full of people like myself ,that are frustrated, hurt , and definitely not better and trying to get off the a/d???
Just the people I have encountered over the last few years have shown that the ones OFF the a/d were feeling much better.
Sorry to be so insistent... IM not a doctor and dont claim to say that my experience applies to everyone,, but i do work in a research lab and understand a little more that the average person about how cells communicate. That is what our particular reasearch lab does.
When i read these posts it really infuriates me to see so many people trapped in this cycle of anxiety, panic, depression, etc. and not getting better by taking the a/d.. or suffering with the withdrawl effects and side effects..
I dont think this is the therapy that will help us battle this disease.. it only masks the symptoms and takes away our human emotions which are supposed to be there for a reason.
I think if we all shed a little more tears and supported each other , we would heal sooner than suppressing our emotions with drugs..
Sorry scott.
just stating my side... thanks for your input
but I know what Im doing with my body and thats getting off the Remeron and feeling good inside againTheres more than one way to skin a cat they say
and this a/d world is not it..im sure you will find I am just one of many who are in the same boat.
Until one takes the drug themselves they cannot judge.
And one has to ask themselves.. if the drug they are taking is truly helping them , then WHY do they keep taking it??? and why are so many people on this site struggling on other meds and STILL NOT RIGHT?? A
Hang in everyone and try to get clean!!
MuskyHi Musky.
>
> I must say that I disagree with your pronouncement that all antidepressants are the same.
>
> > They all affect the same thing in the brain cells.
>
> This is not true. For example, Remeron works in a very different manner than does Prozac. They work to regulate very different aspects of the neuronal machinery.
>
> > and to go from drug to drug is silly,
>
> Most people with a biological affective disorder will respond to at least one antidepressant or drug combination. Recent statistics indicate this to be true.
>
> > as no one drug is better than the other...
>
> This is pretty much what is seen. However, there is some indication that those antidepressants that act to influence two neurotranmitters are more effective than those that act on just one. This is still open to debate, though. It does seem that diffent people react very differently to the same drug just as does one person react differently to different drugs. We need a variety of different drugs to match the great variety of individual biologies. The differences between antidepressants might be subtle, but they are different enough to help a greater number of people.
>
> > If people would only do their research...
>
> I've done quite a bit, and I am led to conclude that it is indeed worth trying different therapies in an effort to treat such devastating illnesses.
>
> It is unfortunate that scientists don't yet understand enough about the workings of the brain in health and disease to be able to design drugs specific to any one illness or any one individual. It is frustrating, I know.
>
>
> - Scott
poster:musky
thread:618809
URL: http://www.dr-bob.org/babble/wdrawl/20060228/msgs/626972.html