Posted by SLS on March 11, 2005, at 7:35:51
Regarding SRI antidepressants and withdrawal:
Short half-life = multiple doses per day
It is silly to assign exclusively the reason for the difficulties withdrawing from drugs like Effexor and Paxil to their relatively short half-lives. It has more to do with their pharmacodynamics (how the drug interacts with the physiology of the brain) than their pharmacokinetics (how the drug is transported through and out of the body).If you want to help mitigate the withdrawal syndrome, it seems obvious that one must take smaller amounts of these drugs several times a day. I don't think this is an inappropriate generalization, and I recommend that people at least try a flexible dosing schedule. I prefer dosing three times a day.
- Scott
poster:SLS
thread:469601
URL: http://www.dr-bob.org/babble/wdrawl/20050228/msgs/469601.html