Re: Experiences with ecstasy during depression?

Posted by TriedEveryDrug on February 24, 2010, at 0:11:01 [reposted on February 26, 2010, at 8:54:34 | original URL]

In reply to Re: Experiences with ecstasy during depression? » em_kath, posted by Economist on February 23, 2010, at 23:11:28

> I've read that taking E with an SSRI simply blocks the effect of E.
Yes, allegedly. Also:

What I have read about SSRIs and E is that taking an SSRI 6 hours or so into an E trip would block the entrance of dopamine (mistakenly) into serotonin terminal vesicles, which E leaves wide open. Dopamine getting into serotonin vesicles results in neuron damage from the H2O2 byproduct of MAO-B deamination of dopamine.
(there is a slide show kicking around the net illustrating the mechanism of neurotoxicity of mdma)
Anywho, I'm not recommending any of the above, nor do I have any experience with it.
I'd love to try MDMA, but how can you know what you're really getting? MDA, which is often in street E is definitely toxic.

Thread

Experiences with ecstasy during depression? Economist 2/26/10
Re: Experiences with ecstasy during depression? » Economist em_kath 2/26/10
Re: Experiences with ecstasy during depression? gman22 2/26/10
Re: Experiences with ecstasy during depression? » em_kath Economist 2/26/10
Re: Experiences with ecstasy during depression? » Economist em_kath 2/26/10
Re: Experiences with ecstasy during depression? TriedEveryDrug 2/26/10
Re: Experiences with ecstasy during depression? rnny 3/19/10

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