Posted by Fred23 on November 8, 2009, at 17:56:16
Would periodic recreational use of nitrous oxide use possibly increase the needed dosage I'm taking of Klonopin for its anxiolytic effect?
The Wikipedia (http://en.wikipedia.org/wiki/Nitrous_oxide) has this paragraph in the Neuropharmacology section:
Unlike most general anesthetics, N2O appears to affect the GABA receptor. In many behavioral tests of anxiety, a low dose of N2O is a successful anxiolytic. This anti-anxiety effect is partially reversed by benzodiazepine receptor antagonists. Mirroring this, animals which have developed tolerance to the anxiolytic effects of benzodiazepines are partially tolerant to nitrous oxide.[13] Indeed, in humans given 30% N2O, benzodiazepine receptor antagonists reduced the subjective reports of feeling high, but did not alter psycho-motor performance.[14]
poster:Fred23
thread:924989
URL: http://www.dr-bob.org/babble/subs/20091027/msgs/924989.html