Posted by CleverGuy on November 1, 2005, at 3:16:15
In reply to Re: Re: Effexor and mushrooms, posted by Matt4444 on September 26, 2005, at 18:55:27
All SSRIs will drastically decrease your ability to "trip". I am not qualified what so ever, and no studies I know of have been done. But from personal experience and reading, I know factually SSRIs will greatly inhibit the desired effects of the popular hallucinagens. I have a guess as to why this is the case. Psilocybin (most active compound in mushrooms) unleashes a quite abnormal amount of seretonin in the brain. This is what makes you trip in fact. SSRIs, as you know, stop the reuptake of seretonin in the brain, keeping levels high. I surmise, especially for those on higher dosages of SSRIs, this is why "tripping" becomes more difficult if not impossible. Basically, the brain is already flooded with seretonin, and most importantly it is quite use to it. If you take effexor you know how you must titrate up to desired dosage; you just can't start popping 300mgs (i bet it would be quite uncomfortable if you did). With all that serotonin in the brain already, there is not a neurological "shock" that most receive after eating mushrooms. It is like pooring water into an already full cup; it just runs down the side and goes nowhere. I am fairly sure this is the case with most hallucinagens. There may be some hallucinagens that don't cuase their desired affects through the process of seretonin flooding, I don't know. If anyone does, please post. As far as the common hallucinagens (lsd, psilosybin, mescalin, mdma), I am quite certain SSRIs inhibit their effects greatly. And depending on your dosage of SSRI, it may make the hallucingen ineffective completely.
Marijuana doesn't work this way, and from personal experience again, SSRIs do not affect the way the brain processes THC. It shouldn't greatly alter your ability to get "high".
poster:CleverGuy
thread:555230
URL: http://www.dr-bob.org/babble/subs/20050914/msgs/574007.html