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Topamax and quitting drinking

Posted by jujube on December 9, 2004, at 14:18:34

I just came across a book called "Dr. Isadore Rosenfeld's Breakthrough Health", in which he states that researchers at the University of Texax Health Science Centre have discovered that Topamax (topiramate), an approved antiseizure, appears to be much more effective in helping alcoholics quit drinking than any other drug available. According to their paper, published in the journal The Lancet, Topamax works by washing away excess dopamine, a chemical in the brain that enhances the craving for alcohol.

The researchers studied 103 heavy drinkers (men who regularly consumed more than five drinks a day and women who took more than four), all of whom had already tried and failed Alcohol Anonymous, drug therapy, psychotherapy, and rehabilitation clinics. 55 subjects were given oral Topamax; the remaining 48, a placebo. At the end of the study, 24 percent of those taking the topamax had abstained completely for 1 month, compared with only 4 percent of the placebo group. Another plus for topamax was that it improved abnormal liver function caused by alcohol excess in some patients. It also lifted mood and relieved anxiety symptoms.

Patients on topamax do not have to abstain completely. However, if they do continue to drink, they do so less than before.

Tamara


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