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Re: Might Opiates in Moderation Fight Depresion?

Posted by MysticalMeds on November 28, 2003, at 16:07:53

In reply to Re: Might Opiates in Moderation Fight Depresion?, posted by bsj on November 23, 2003, at 21:09:26

bsj, does the same doctor who perscribes your wellbutrin give you the hydrocodone? what time of day do you take the 2 pills?

YoMeMe,

try http://opioids.com & www.biopsychiatry.com
there's no doubt in my mind that opium derivatives are the only way that a small percentage of people with depression will ever truly feel normal. As i am of limited means, i excercise daily, which releases endogenous opioids, equivalent (subjectively) to maybe 2 or 3 milligrams of hydrocodone.

***********

In classical antiquity, Aristotle - admittedly not always the soundest authority on medical matters - classified pain as an emotion. Opium was a traditional remedy for melancholic depression; its efficacy is arguably superior to Prozac, though controlled clinical trials are lacking. In "animal models", opioids reverse the depressed behavior, learned helplessness and neuroendocrine responses associated with clinical depression. By contrast, opioid antagonists such as naloxone exacerbate them. To confuse matters further, sufferers of depression typically share an increased sensitivity to pain; and modern "antidepressants" can themselves act as "physical" painkillers. Conversely, mu-opioid receptor agonists offer both unsurpassed pain-relief and extraordinary emotional well-being; and delta-opioid agonists and enkephalinase inhibitors can function as antidepressants. There is clearly an intimate link between "physical" and "emotional" pain. In defiance of dualist metaphysics, the opioids tend to be best at banishing both.


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poster:MysticalMeds thread:280166
URL: http://www.dr-bob.org/babble/subs/20031014/msgs/284799.html