Posted by chdurie2 on October 24, 2000, at 11:32:30
In reply to Wellbutrin and Provigil » chdurie2, posted by Angela5 on October 24, 2000, at 0:12:23
> Caroline -
>
> Thanks for the info. I've been on low dose (150 mg/day) of Wellbutrin SR since June. Myself/my pdoc have been combining it with various SSRIs, and now I will probably be going to an MAOI. Anyway, I also seem to need a stimulant. In August I began taking Cylert, which seems to help, but which scares me due to the liver issues, so at one point recently I tried Provigil instead. I find it kind of scary that neither my pdoc nor my pharmacist (or Walgreen's computer, for that matter) ever mentioned an interaction. I didn't experience the "flying," although that may have been due to dose. Provigil made me very tired, which I understand usually goes away, but it also gave me nasty headaches. I'm wondering if this could have anything to do with the interaction...?
> Adrafinil (which I tried before the Cylert) had also given me headaches - possibly an interaction there, as well? Adrafinil, out of all three, had the most favorable impact on my concentration and motivation.
>
> I'm now back on the Cylert (due to the fatigue/headaches with provigil), but I find this very interesting, since I would much prefer a different stimulant. I take Hytrin to counteract the sweating from the Wellbutrin, and Hytrin and Cylert seem to interact, causing RAISED blood pressure and heart palpitations (which disappear with either individually).
>
> Sorry, this turned out to be much longer than I had intended. :)
>
> AngelaAngela- I'm not a psychopharmacologist, so i have no idea why you're tired and getting headaches - from the provigil, i'd guess that it's the contraindication i spoke of with wellbutrin - overstimulation in a certain part of brain - similar to my "flying" reaction.
but more importantly, recently there have been cylert (pemoline) alerts of danger on various medical websites. i saw it posted several places last night when i was looking for something else. either pemoline is being pulled from the market, or the liver dangers are worse than previously thought. i don't remember where i saw this stuff- but some of the websites i was on were ebiotech, medcape, micromedex, the fda recall website, etc.
i was looking for any possible news of whether a certain brand of intravenous gamma globulin fda-recalled in 1998 caused Hepatitis B, and although everyone had the recall listed, there was no mention of Hepatitis B. But several sites had the new dangers of pemoline listed, and maybe even a recall.
i'd try plugging pemoline into the alta vista search engine, and that would probably pull it for you. and i'd talk to p-doc about going off the stuff. you don't want to wait until a liver test tells you your liver is screwed up.
what's adrafinil? i just saw it on psycho-babble, where someone was looking for a european place they could order from, so i assumed it was a nootropic you had to get on the overseas internet market. i'll also ask my p-doc about it, cuz i am looking for a better way.i'd do just about anything before trying an MAOI-Class A (nardil, parnate) but you're talking to someone who had a near-fatal hypertensive incident just from drinking a chocolate milkshake. and i have low blood pressure. my p-doc said i must be pre-disposed chemically.
If i didn't say so earlier, i'm pretty happy with Eldapryl (selegeline,) which has a small amount of amphetamine in it, and is pretty mild but effective as an anti-d. there's some contraversy about whether you have to observe the dietary restrictions on it (i don't now, but i don't eat a lot of that stuff anyway.) you can do a search on selegeline on dr. bob's pharmacology tips or i think, psycho-babble if you're interested.
anyway, this post is mainly to alert you to the new dangers found in pemoline.
caroline
poster:chdurie2
thread:1292
URL: http://www.dr-bob.org/babble/social/20001011/msgs/1557.html