Re: 'Prozac not potent (...)' - Yes it is!

Posted by West on March 14, 2010, at 19:34:15

In reply to Re: 'Prozac not potent (...)' - Yes it is!, posted by Brainbeard on December 30, 2009, at 13:45:29

In Pigs: agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively. It also interacted with h5-HT2B receptors (6.6), whereas it showed low affinity at native (rat)/cloned, human 5-HT2A (<5.0/5.3) and 5-HT1A (<5.0/5.2) receptors, and negligible (<5.0) affinity for other 5-HT receptors.
From http://www.ncbi.nlm.nih.gov/pubmed/12750432

Thread

Prozac not potent 5-HT2C antagonist conundrum 11/26/09
Re: Prozac not potent 5-HT2C antagonist mtdewcmu 11/26/09
Re: Prozac not potent 5-HT2C antagonist » mtdewcmu conundrum 11/27/09
Re: 'Prozac not potent (...)' - Yes it is! Brainbeard 12/30/09
Re: 'Prozac not potent (...)' - Yes it is! » Brainbeard mtdewcmu 12/31/09
Re: 'Prozac not potent (...)' - Yes it is! Brainbeard 1/2/10
Re: 'Prozac not potent (...)' - Yes it is! West 3/14/10
Re: 'Prozac not potent (...)' - Yes it is! Franz 4/2/11
Re: 'Prozac not potent (...)' - Yes it is! Brainbeard 4/3/11
Re: 'Prozac not potent (...)' - Yes it is! » Brainbeard Franz 4/3/11
Re: 'Prozac not potent (...)' - Yes it is! Brainbeard 4/3/11

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