Posted by Brainbeard on January 3, 2010, at 10:31:23
In reply to Re: 5HT Receptors, posted by mtdewcmu on January 2, 2010, at 17:18:43
> Maybe it tends to stay in the body rather than accumulating in the brain, and therefore attacks the gut. Prozac is the opposite; brain concentrations wind up much higher than concentrations in the blood.
Well, it doesn't just seem to be a 'gut thing'; Luvox is supposed to work especially well for OCD, and this is supposed to be related to its action on 5HT3 receptors. 5HT3 receptors play a role in the release of dopamine and dopamine release plays a role in the reward mechanism of compulsive acts. 5HT3 antagonism blocks this reward mechanism.
Your theory is an interesting one.
poster:Brainbeard
thread:896245
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/932294.html