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Re: How did Prozac cause my permanent Anhedonia » sowhysosad

Posted by metafunj on September 15, 2009, at 21:51:53

In reply to Re: How did Prozac cause my permanent Anhedonia » metafunj, posted by sowhysosad on September 15, 2009, at 21:03:29

Yeh, I just hope I'm right. I've been dealing with this long enough.

I based this on the following study and also that the feelings I have are generally ones people feel on SSRIs who need a dopamine boost.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T26-4FNW4KX-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1013167935&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e2d014a4e9068b08a9a28ce51950fa64

SERT and DAT availabilities under citalopram treatment in obsessive–compulsive disorder (OCD)

Abstract

"Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]β-CIT and single photon emission computed tomography in subjects with obsessive–compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain."

--------------------------------

Its interesting that Andrewfromdenmark feels the same as he did now as when on lexapro which is completely selective to the serotonin transporter while Wanderer and I only felt that way after stopping prozac thus removing 5HT2C antagonism.

I also read in another thread that andrew's anhedonia was improved by remeron which blocks the 5HT2/C and 5HT3 receptors. This blocks the agaonism of serotonin and causes a release of dopamine.

So if we want to base treatment on this theory:
1. we should take 5 HTA2/C or just 5 HT2C blocking drugs. ie low dose (2.5mg) prozac, remeron, Cyproheptadine.

2. We could take serotonin reducing drugs like Buspar or Tianeptine. I think Buspar sounds better than a drug that acts on SERT like Tianeptine. When you already have less transporters you don't wanna go messing them up. Ginkgo is supposed to suppress the release of serotonin as well.

3. Dopamine boosters. Too many too name the stimulants, agonists, parkinson's restless leg drugs, provigil. ok maybe not that many :)

Any of these groups could help alone or in tandem with a drug from another group.

PS: I hope I've reflected andrew's and wanderer's experiences correctly.

 

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poster:metafunj thread:914929
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