Posted by metafunj on September 12, 2009, at 11:23:47
In reply to Do SSRI's cause dopamine depletion, posted by Alexanderfromdenmark on March 3, 2009, at 10:46:37
Just thought I'd throw this in here. I posted it in the tread about dopamine depletion on SSRIs being a myth. I hope this helps to answer the initial question.
Abstract
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]β-CIT and single photon emission computed tomography in subjects with obsessive–compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
Keywords: Serotonin and dopamine transporters; Single photon emission computed tomography; β-CIT; Serotonin reuptake inhibitor; Obsessive–compulsive disorder
poster:metafunj
thread:883495
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/916659.html