Posted by SLS on April 13, 2009, at 8:06:07
In reply to Re: Dopamine depletion: A myth? » sowhysosad, posted by Amelia_in_StPaul on April 12, 2009, at 21:41:46
> I thought neuroleptics were dopamine antagonists. You're saying that they stimulate DA?
>
> > You just need to stimulate the DA nerves to fire. This can be accomplished by using stimulants, Wellbutrin, and possibly atypical neuroleptics.Hi Amelia.
Some of the neuroleptics are known to stimulate the synthesis and release of DA through the selective blockage of presynaptic autoreceptors. Sulpiride and amisulpride are examples of this. Abilify (aripiprazole) accomplishes DA enhancement by acting as a partial agonist at DA postsynaptic receptors.
- Scott
poster:SLS
thread:889604
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/890315.html