Posted by desolationrower on December 1, 2008, at 15:06:29
In reply to Re: Considering an MAOI, posted by Lowell on November 30, 2008, at 10:03:08
HI Lowel, welcome to the board. I agree with what you have said, except that the patch is generally safe for tyramine. There have not been any reported reactions with it that i'm aware of. The patch gets the MAOI deprenyl directly into the blood, so less of the intestinal MAO is inhibited: thus, it is still there to destroy dietary tyramine. Additionally, deprenyl has some peculiar properties that make it inhibit the tyramine pressor effect, such that it is the least likely of the irreversable full MAOIs to hypertensive crisis. Unfortunatly giving someone oral deprenyl and then seeing the effect of tyramine hasn't been tested, and is not something one can do safely at home, so it isn't clear how strong this effect is. It may be related to the amphetamine metabolites blocking tyramine uptake, or maybe something else. Unfortunatly itdoes seem to be a somewhat weaker antidepressant than the other two MAOIs that are more studied, at least anecdotaly. I didn't notice as strong effect from it as from tranylcypromine, although deprenyl gave me a giant libido boost. All the MAOIs have other effects besides the inhibition of MAO, so one's reaction to them is probably going to vary more than to some other drugs. But i think they are all very useful and parnate for me has been the only antidepressant to work.
-d/r
poster:desolationrower
thread:826622
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/866102.html