Posted by SLS on May 23, 2008, at 15:45:11
In reply to Re: Sulpiride and Abilify questions..., posted by undopaminergic on May 23, 2008, at 15:37:34
> > > I think aripiprazole (Abilify, APZ) is regarded as a full agonist at presynaptic dopamine (DA) (auto)receptors. This reduces DA synthesis and release, and is likely to be contrary to what you're looking for.
> >
> > Not necessarily. One must look at all of the properties of aripiprazole.> Right, so why do you quote - out of context - only one part of a message that looks at the properties most relevant to predicting how it will it will interact with sulpiride?
Feel free to post the entire article. You can use the link I provided.
> > Postsynaptic agonists overule presynaptic agonists because they directly stimulate postsynaptic receptors regardless of the decrease in DA synthesis and release.
> That is dose dependent.No. It is DA concentration dependent. I thought the article was clear about that. This is a well known property of this drug. Check out what Stephen Stahl, MD has to say about it.
Try reading the article. It won't take that long.
- Scott
poster:SLS
thread:829749
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/830742.html