Posted by John Doughboy on May 10, 2008, at 18:39:16
In reply to zoloft wellbutrin - dosage??, posted by baracuda on February 17, 2008, at 2:36:19
It's funny that you mentioned this, because I'm also on 100mg of Zoloft and my mood is totally flat. When I took Wellbutrin for a couple days one time I got an effect that was vaguely "psychedelic" (you said it felt a little like ecstasy?).
Speaking of MDMA,its main mechanisms of action are that it attaches to the same reuptake site that SSRI's bind to (SERT) and reverses the flow of serotonin. It basically makes the reuptake site pump serotonin out instead of taking it in like it normally does (while also keeping the serotonin in the synapse from going back to the pre-synaptic cell because the reuptake site is already blocked). It also does this to dopamine, but much less than serotonin.
What I'm getting out is that SSRI plus Wellbutrin might be like some kind of really weak pseudo ecstasy.
poster:John Doughboy
thread:813224
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/828370.html