Posted by undopaminergic on May 1, 2008, at 2:31:08
In reply to Creativity? for undopaminergic and others, posted by cumulative on April 14, 2008, at 0:29:01
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> Given the effects you describe, albeit creativity being far more complex than all this, I would somewhat expect the opposite -- an improvement in, say, associative idea generation.
>That is precisely what I experienced during one of several trials of amantadine (of which memantine is a dimethyl-derivative), to the point of an overwhelming hypomanic-like flight of ideas.
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> So, what do you think, undopaminergic? What did memantine do for you in this respect, creativity?
>There is certainly an improvement thereof in the short term, but I need more time to determine whether it is persistent or subject to tolerance. My observations are currently further confounded by the simultaneous use of a SSRI (escitalopram), which I suspect may be dampening what might otherwise turn into the kind of hypomanic flight of ideas noted with amantadine.
> Did you seem to suffer any cognitive impairment from the memantine?
>I've found that starting at a high dose (20 mg or more) can produce a state of cognitive impairment, and - for lack of a better term - a sense of intoxication. I also note that Scott reports a similar experience of feeling drunk after a 40 mg dose. Fortunately, a high level of tolerance develops rapidly (within a day or two) to these adverse effects.
poster:undopaminergic
thread:822260
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/826541.html