Posted by Darwin on July 9, 2005, at 15:42:05
In reply to Doxycycline for osteoarthritis..., posted by ed_uk on July 8, 2005, at 15:32:19
Low dose (20mg/day) doxycyline is also used to treat periodontal disease. At 20mg/day, its mode of action is as a collagenase inhibitor and not as a antimicrobial. I suspect that its beneficial effect in treating osteoarthritis is also due to its collagenase inhibition. If so, perhaps a dose of 20mg/day would have worked as well as the higher dosage used in the study.
poster:Darwin
thread:525306
URL: http://www.dr-bob.org/babble/health/20050411/msgs/525499.html