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Olives! Re: Which Antioxidants do not have CYP...

Posted by Mtom on July 12, 2020, at 14:29:18

In reply to Which Antioxidants do not have CYP interactions?, posted by Lamdage22 on July 3, 2020, at 3:23:54

Doing some research I came across a link to this article from 2015:
https://journals.sagepub.com/doi/10.1177/0141076815599673 From alga to omega; have we reached peak (fish) oil?

And here is a short excerpt (but worth reading the whole article):

Supplementing the diet with purified omega 3 fatty acids can increase lipid peroxidation, as measured by plasma MDA release and lipid peroxide products, and this is not suppressed by vitamin E supplementation.
Promising alternative antioxidants include lipophilic polyphenols such as the secoiridoids and phlorotannins. Unlike many of the hydrophilic polyphenols, the olive compounds have excellent bioavailability.39 This was recognised by an EFSA-approved health claim that that a mere 5 mg/day of secoiridoids was sufficient to protect LDL cholesterol from oxidative damage.
Once olive polyphenols enter the blood they become integrated into the lipoproteins which carry cholesterol and other lipids round the body and protect the lipoproteins including their lipid components from oxidation. At the same time, they target the artery walls where they exert anti-inflammatory effects including the inhibition of the tissue-destructive MMP group of enzymes. This is a powerfully cardio-protective strategy, and when combined with omega 3 highly unsaturated fatty acids, the two sets of actives provide a potent anti-inflammatory, anti-atherogenic and cardio-protective environment.
The olive polyphenols are now regarded as playing a key role in the health-promoting benefits of the Mediterranean diet."

On the other hand, if you start searching the literature, you can find papers describing how just about all the good compounds in plants (e.g. various polyphenols etc.) can potentially affect P450 CYP enzymes in different ways (enhance, inhibit, etc).

"Personalized Medicine" taking all things into account is on the (perhaps somewhat distant) horizon. In the meantime, all I can think of is a mixture of experimentation and consistency in eating an anti-inflammatory diet perhaps supplemented with small to moderate doses of supplements. A change in dose of medications might be necessary to offset any CYP effects, and that will be the difficult part as no Docs I've encountered know much (if anything) about these interactions.

I have however read several papers that have speculated that such interactions - herb-supplements-foods-medications may be responsible for some proportion of therapeutic failures....


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