Posted by bleauberry on January 15, 2014, at 9:09:26
In reply to Sam-E serotonergic but not dopaminergic?, posted by Lamdage22 on January 5, 2014, at 4:52:54
I do not believe you can pin down SAMe mechanisms exactly because they are too many. Methylation happens all over the body. Depending on the particular person, we will never know what it was about SAMe that helped them feel better....
-was it the extra methyl groups?
-was it the sulfur?
-was it the adenosyl?
-was it serotonin or dopamine?You'll never know. The only way to know if it is helpful to you or not is a personal trial.
I tried it because literature suggested strongly that there is a dopamine connection there. Maybe the first couple days I felt some dopaminergic stuff, but that faded away. After that, guess what happened.....numb, flat, the same as SSRIs! I couldn't believe it!
Why? Sound like too much serotonin right? In reality, we will never know.
I love armchair quarterbacking....figuring out in advance exactly what a substance will do and how that might fit my needs....but in the real world I have not seen that produce real results. Due to the lack of knowledge of what disease we are actually dealing with in our own body, the lack of complete understanding of all the mechanisms of a substance, and the fact that paradoxical reactions happen, armchair quarterbacking of SAMe isn't going to get any of us anywhere. The only way is to set the research on a shelf, go buy some SAMe, and start taking it.
poster:bleauberry
thread:1057839
URL: http://www.dr-bob.org/babble/alter/20131226/msgs/1058593.html