Posted by linkadge on September 17, 2010, at 8:31:53
In reply to Re: trying a new (simpler) regiment, posted by morgan miller on September 15, 2010, at 14:00:14
>Maybe add half a dose of a good multivitamin if >you feel like you might not be getting >everything.
I don't do that well on multivitamins for some reason. I havn't filtered out whats helping me and whats hurting me. Some of the b complex just end up giving me nervous energy which I don't need. The niacin is different.
I do believe there is some genetic predisposition to particular problems. But, I also feel that there are possible nutritional targets for the same pathways as drugs.
For instance, niacin is a potent GSK-3b inhibitor like lithium and valproate. GSK-3b inhibition produces neurotrophic and neuroprotective effects. Inhibiting gsk-3b also produces antipsychotic effects in animal models as well as ability to reset the circadian clocks.
I was reading an article on the utility of gsk-3b inhibitors on psychosis. They then mentioned how this might be a theraputic target of lithium and valproate augmentation. But, then, I was thinking to myself, wait! niacin is a potent GSK-3b inhibitor, could this be a mechanism for its purported efficacy in schizophrenia??
Perhaps, its not so much that schizophrenics are deficiacnt in niacin. Instead, perhaps in high doses, the supplement starts to affect targets common to mood stabilizers. Like PKC inhibition with high dose omega-3
Inhibiting GSK-3b has some ability to modulate the sensitivity to dopamine.
Linkadge
poster:linkadge
thread:962300
URL: http://www.dr-bob.org/babble/alter/20100812/msgs/962724.html