Posted by tea on December 29, 2009, at 1:49:30
In reply to Re: DHEA : cortisol ratio - possible link to panic, posted by tea on December 28, 2009, at 15:20:41
> > Re prolactin, I listened to a presentation of some studies on prolactin /cortisol I think in birds and aggressive behaviour etc(destruction of nest?)- sorry I also forget this(about 6 years ago).
> I do vaguely recall that prolactin is a desired response to the high cortisol? I'll try to do a quick search for the study but don't hold much hope in locating. I found it interesting as nothing else had touched on the subject beforehand.. but yes its linked in there for sure!
>>OK found the talk. It says(and these were respected scientific lecturers)..."because of the known inhibition of PRL by glucocorticoids, and the inverse relationship between glucocorticoid secretion and body condition, we evaluated the the relationship between the body condition ...and plasma PRL levels"
Basically the poor condition birds had lower PRL levels by the 2nd shift of incubation and it was suggested that the as PRL promotes breeding behaviour the low PRL probably plays a role in nest abandonment when body reserves were low"
so nothing mentioned about DHEA, only it seemed to be saying that cortisol higher would inhibit prolactin? as if it was a known fact-
opposite of what you are saying(or the article you are referring to was suggesting). Then again it is birds, but there usually is similarities between species to a point. So my apologies for that! I'm not thinking well, so I will try not to respond in future!BTW I guess you were referring to http://www.anthropogeny.com/A%20Hypothetical%20Explanation%20of%20Panic%20Disorder.htm
abstract: "Panic attacks may result from severe reduction of dehydroepiandrosterone (DHEA) in a person of low DHEA with normal or increased levels of cortisol. That is, an excessive ratio of cortisol to DHEA occurs which extinguishes the effects of unstable DHEA and magnifies the effects of cortisol. Prolactin increases during panic attacks and is correlated with attack severity. That is, prolactin increases to stimulate DHEA, but the response is inadequate to stabilize the DHEA to cortisol ratio and inhibit prolactin production. Therefore, prolactin remains elevated during an attack. Panic attacks occur when the effects of excessive cortisol excite prolactin stimulation of DHEA in a person who cannot respond with adequate DHEA"Sorry I'm not capable of commenting, so I won't try, but I think anything invovling stress and panic should consider adrenaline/noradrenaline as well as cortisol - so I don't think I'd give it that much credit? So NO comment(other than to show it may disagree with glucocorticoids suppressing PRL? Beats me and sorry for incorrect info in above post
PS I gave up on trying to work out how it all fits together as there are way too many hormones, receptors, neurotransmitters and you just can't consider them much individually or even in small groups except for a few basics under certain condtitons..and they haven't even "discovered" them all as yet.. so I think it's best just to see how things work with you or others(especially blood relatives helps!) as genetics also plays a part in how all this stuff works:-) Still I do understand the desire to figure out at least a bit of it all.
poster:tea
thread:917023
URL: http://www.dr-bob.org/babble/alter/20091202/msgs/931369.html