Liver enzyme table

Posted by cache-monkey on February 14, 2008, at 20:57:33

In reply to St JW contraindications?, posted by Basia on February 13, 2008, at 1:43:53

There's a doctor at IUPUI who's created a nifty chart covering many CYP interactions:
http://medicine.iupui.edu/flockhart/table.htm
[Caveat: I don't think this is 100% complete ...]
If you're new to this, inducers speed up an enzyme, which makes a substrate process out faster. Inhibitors do the opposite, slowing down the elimination of substrates leading to higher circulating levels.
For your purposes: quetiapine (Seroquel) is a substrate of CYP-3A4; St. John's wort is an inducer of the same enzyme. This means that your effective blood level of Seroquel will go down (by some indeterminate amount) if you take SJW.
Hope this helps. Again, remember that the table is not necessarily complete.
Good luck,
cache-monkey

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St JW contraindications? Basia 2/13/08
Re: St JW contraindications? » Basia bleauberry 2/13/08
Liver enzyme table cache-monkey 2/14/08
Re: Liver enzyme table Basia 2/15/08

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