Posted by KayeBaby on April 21, 2007, at 20:58:57
In reply to Re: Pregnenolone » Tom Twilight, posted by Larry Hoover on April 21, 2007, at 11:59:44
> > Pregenalone really calms me down
> >
> > Its bizare since DHEA makes me anxious, I thought they were more or less the same thing?
>
> With respect to neuroactive steroids, it is the difference between the substances that makes all the difference. It is a mistake to assume that because they are hard to tell apart by chemical structure, that they also have similar function. As far as their effects go, they are very different.
>
> One immediate effect of pregnenolone is to stimulate the same dopaminergic reward pathway as does morphine. However, a chronic effect is to downregulate GABA-A receptor sensitivity. I would assume there are numerous other effects, both primary and secondary, because that is a basic property of a hormone, to have huge effects at tiny doses. I think you're playing with fire.
>
> Lar
>
>Hey Larry,
This why I am not taking it. I bought it on a whim (it was cheap) and there it sits.
I learned that hard way that random messing around with hormones can have some really bad effects. At the same time I also experienced some remarkable benefits from messing with them so I am intrigued. Wish I could find a Dr. that knows what he is doing with them.
Peace,
Kaye
poster:KayeBaby
thread:751328
URL: http://www.dr-bob.org/babble/alter/20070410/msgs/752166.html