Posted by Larry Hoover on January 25, 2007, at 6:14:56
In reply to Re: Curcumin - HPA axis, posted by linkadge on January 24, 2007, at 19:13:48
> Is curcumin the ingredient responsible for Cox-2 inhibtion?
Yes. It also down-regulates the gene for COX-2.
> If so, the cox inhibiton and MAO inhibiton are inseperable (?)
Looks like, but the COX inhibition is stronger, IMHO.
> Yes, for a few weeks, I ingesteed about 10 grams of curry powder per day.
>
> Around a 60g bottle per week.Whoa! You are quite willing to do these experiments, aren't you? BTW, curry powder is not considered to be a reliable source of curcumin....being a highly variable mixture of spices, including turmeric. I just buy turmeric at the bulk store. I think I estimated a teaspoonful costs 3 cents, or something.
> I do not know if doses this high are critical for an antidepressant response though. I am not a believer in the notion that a certain degree of MAO inhibiton must be achieved for an antidepressant response.I agree. A relative reduction, held stable with long-term dosing, is probably sufficient.
> As you had mentioned before, the anti-inflamitory action may be responsable in part for the psychologial effects of turmeric.It's quite possible that neuroprotective effects are psychologically stabilizing.
> I know you doubt my discriminative abilities, I bet I could tell you the difference between a 1 gram capsule of turmeric, and 1 gram of a substance with equlivilant antinflamitory capacity.I don't doubt you, link. And I think I might be able to do the same thing. We are independent thinkers, and that brings us into opposition. The relative value of various bits and pieces are differentially assessed by the two of us. That's much better than if we preached to a choir.
> Another tip off was that I would get symptoms of mild serotonin syndrome if I combined as little as one gram of turmeric with citalopram.
>
> LinkadgeI never thought of that. Thanks for sharing your experience.
Lar
poster:Larry Hoover
thread:726034
URL: http://www.dr-bob.org/babble/alter/20070114/msgs/726261.html