Posted by Larry Hoover on January 21, 2007, at 9:23:47
In reply to Re: Fish oil aborption » saturn, posted by dessbee on January 12, 2007, at 6:46:31
> I do not think you need to worry about absorption if you get side effects from fish oil.
> Then it will just be a matter of right dosage to avoid side effects.
>
> If you want the best value for the money you could crush the fish oil capsule with your teeth so parts of the fatty acids is absorbed without first pass metabolism in the liver.
> Unfortunately this has a fishy aftertaste... and your friends might dislike it ;-)
>I kind of doubt that there would be substantial oral uptake of triglycerides....but I could be wrong.
Intestinal absorption of triglycerides involves complete hydrolysis of the fats, so the liver's job is to reconstitute triglycerides from glycerol and free fatty acids. Yes, the liver gets first shot at taking up EPA and DHA, which it needs for proper functioning.....but that's not really a first pass metabolism effect.
It takes considerable time to allow membrane fatty acid composition to optimize via normal turnover, with available resources of EPA and DHA.....perhaps up to 18 months of regular intake. It doesn't have to be daily intake, but regular intake. The liver fairly randomly reassembles triglycerides from the free fatty acid pool, so your job is really just to make sure that there is some EPA and DHA available, over spans of days.
Lar
poster:Larry Hoover
thread:721498
URL: http://www.dr-bob.org/babble/alter/20070114/msgs/724738.html