Posted by linkadge on January 13, 2007, at 21:54:00
In reply to Re: Controversial treatment for depression/anxiety » Jimmyboy, posted by fayeroe on January 12, 2007, at 18:32:25
Psychedellic compounds may have utility in obsessive compusive disorders.
If you block the 5-ht2a/c receptors, then SSRI's usually loose their antiobsesive qualities.
A number of hallucinogens are potent 5-ht2a/c receptor agonists. Esp mescaline.
People with OCD lack insight. There is a problem with overactivation of the frontal cortex, and underactivation of the parietal lobes (awareness).
The two work on kind of a yin-yang. Typically the frontal cortex disenguages and the paretal lobes kick in, upon completion of a task, to asess the overall significance of the action, without this shift, the action never seems complete.Im theory, the psychedellics can help ocd by activating gabaergic currents in the frontal cortex via 5-ht2a/c, and by activating the paretial lobes, to restore the delicate ballance between the two.
Anyhow, psychedellic experiences are not restricted to psychedellics. Just like there are endogenious amphetamines, there are endogenious psychedellics like tryptamine.The use of monoamine oxidase inhibitors are mildly psychedellic in that they potentiate the activity of tryptamine.
Perhaps the higher efficacy of the MAOI's in OCD has to do with their potentiation of trace amines like the serotonin agonist tryptamine?
Linkadge
poster:linkadge
thread:720803
URL: http://www.dr-bob.org/babble/alter/20061218/msgs/722095.html