Posted by dessbee on January 4, 2007, at 8:19:36
In reply to Re: Alcohol enhances neurogenesis, posted by nolvas on January 4, 2007, at 2:24:32
Alcohol increases release of serotonin and dopamine in CNS. Dopamine increases in reward centers of the brain (the ventral tegmental area).
Alcohol enhances GABA-mediated responses. GABA is an inhibitory neurotransmitter and the GABA receptor is an important site of action for benzodiazepines and barbiturates.
Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism
Alcohol enhances the conversion of dihomogammalinolenic acid (DGLA) to PGE1 but it blocks the activity of the delta-6-desaturase, an enzyme necessary for replenishment of DGLA stores from dietary precursors. The acute effect of ethanol is therefore an increased production of PGE1 but chronic consumption will lead to depletion of DGLA and PGE1. To avoid depletion it's necessary to drink moderately.
http://serendip.brynmawr.edu/bb/neuro/neuro00/web1/Kim.htmlhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1701092&dopt=Abstract
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=42388
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6253773&dopt=Citation
poster:dessbee
thread:718981
URL: http://www.dr-bob.org/babble/alter/20061218/msgs/719214.html