Posted by sdb on December 5, 2006, at 16:44:46
In reply to Linkadge, SJW Input Please, posted by blueberry on December 3, 2006, at 15:33:17
> Hi Linkadge,
>
> What brand of SJW are you taking?
>
> I started Kira LI160 2 weeks ago at the same time I stopped 10mg prozac. I have carefully slowly increased the dose from 150mg to 550mg as the prozac washes out.
>
> I have two clinical brands onhand. Kira and Remotiv ZE117 (ordered from overseas). I started on Kira and take 300mg of it. I am taking Remotiv with it at 250mg. I can't decide which brand to stick with or whether I should keep combining them. From researching pubmed clinical studies and other google searches Remotiv looks like the best brand going, even though it doesn't have hyperforin.
>
> Anyway, any input? Thanks.Ze 117 has done some good studies so there is evidence that Ze 117 can work. But there is not much data, not many studies available and some were probably influenced by pharmaceutical companies. If there's no hyperforin it does not mean that hypericum does not work. In some studies hypericin and hyperforin were gradually removed but a lot of other substances of the extract had still big influence on the brain chemistry. If you
take Ze 117 without hyperforin you will definitely have the advantage for less drug interactions e.g. drugs metabolized by CYP3A4 (and there are many) thus benzodiazepines will continue to work and there are less interactions with other drugs.sdb
Most recent study:
Vitamin E Reduces Antidepressant-Related beta-Adrenoceptor Down-Regulation in Cultured Cells. Comparable Effects on St. John's Wort and Tricyclic Antidepressant Treatment.
The mode of action of antidepressants is still a matter of debate. Acute inhibition of neurotransmitter reuptake in central neuronal synapses, followed by a down-regulation of central postsynaptic beta-adrenoceptor (beta-AR) numbers were consistently observed IN VIVO, while a reduction in surface beta-AR density was found in cell cultures. Effects of the tricyclic antidepressant desipramine (DMI) were abolished by vitamin E (alpha-TOC) IN VITRO as well as IN VIVO. alpha-TOC interfered with antidepressant-induced changes of cellular plasma membrane properties and with recycling of beta-AR. St. John's wort (SJW) extract reduced beta-AR numbers in cultured cells to a similar extent as DMI or the selective serotonin re-uptake inhibitor fluoxetine. We chronically co-exposed cell cultures to SJW extract and to alpha-TOC. Receptor down-regulation following exposure to the plant extract was inhibited in the presence of alpha-TOC suggesting a mode of action of SJW extract comparable to that of synthetic antidepressants. Inhibition of cell proliferation by the plant extract was also significantly reduced by alpha-TOC. alpha-TOC:alpha-Tocopherol, vitamin E beta-AR:beta-Adrenoceptor C6 cells:Rat glioma C6 cells DMI:Desipramine SD:Standard Deviation SJW:Saint John's Wort SSRI:Selective Serotonin Reuptake Inhibitors TCA:Tricyclic Antidepressants Ze 117 extract:Saint John's Wort extract Ze 117.
PMID: 17109256 [PubMed - as supplied by publisher]
poster:sdb
thread:709993
URL: http://www.dr-bob.org/babble/alter/20061203/msgs/710656.html