Posted by tealady on October 2, 2006, at 0:55:03
In reply to Re: 24 hour cortisol salivary results (need help i, posted by sregan on October 1, 2006, at 18:01:37
> I think my cortisol curve matches what one would expect for "melancholic" depression. I'm addressing the HPA overshoot at night that is my target. Drugs like imipramine and amitryptaline are supposed to help reset the HPA.
You're ahead of me.
I do think your curve needs restting though, not necessarily "lowering" of cortisol, as it isn't up high all thru the day, and I agree if you do get it "reset" then the highs will probably not be as high.
Do you have difficulty going to sleep at night with that high a cortisol level?
I couldn't stay awake til 11Pm little only midnight when I sampled my saliva cortisol , and I took the midnight one about 10:30PM.. by then it was undetectable low), but my morning one was OK (noon and aft on low side).
I figured for me the Undetectable cortisol was why I couldnt stay awake despite pinching myself
I tried Tri-cyclic antiD's about 15 yrs ago.. they didnt help me, but we are all individual.
I see you realise that these drugs also have an effect on cortisol levels..as well as wothdrawal from same.
Also there's a thyroid-pituitary-hypothalamus axis.. and cortisol affects this too, and it affects cortisol..so I think the HPA axis is a bit simplistic (but easier to teach).You mention a form of carnitine as well.
i'd assume B vits would also affect it (B1, B5 for starters?)
Sorry I can't help, as I feel you know more than me here:)
poster:tealady
thread:687103
URL: http://www.dr-bob.org/babble/alter/20060817/msgs/691033.html