Posted by saturn on September 14, 2006, at 19:16:30
In reply to Re: how high can you go with epa, total fish oils? » saturn, posted by Jlx on September 14, 2006, at 18:11:32
> This page is a summary of research to date. http://www.psycheducation.org/depression/meds/Omega-3.htm#FishTable
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> Note that sometimes gram doses are EPA/DHA and sometimes grams are of fish oil.
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> EPA and DHA amounts per softgel may differ widely brand to brand, but are often 180/120 respectively.
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> I take Natural Factors, RxOmega-3 Factors Pharmaceutical Grade, which contains 400 mg EPA and 200 mg DHA per capsule. 240 capsules is $23.05 at iherb, approximately 10 cents per capsule. http://www.iherb.com/store/ProductDetails.aspx?c=Herbs&pid=NFS-35491
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> High doses of fish oil increasing chance of stroke has been one adverse consequence I've read about in the past, but in this article...
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> Fish oil: what the prescriber needs to know
> Arthritis Research & Therapy 2006
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> http://arthritis-research.com/content/8/1/202
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> the "Safety" discussion of this article notes that the bleeding tendency in Inuits with their high Omega-3 consumption occurs within a context of low dietary Omega-6.
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> "Within the Western context, fish oil supplements have not been associated with an increased bleeding tendency, even in patients taking aspirin or warfarin for antithrombotic effect."
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> That article also notes that to obtain the inflammatory effect of fish oil such as for arthritis, as many as nine capsules may be needed (to provide 2.7 gm EPA).
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> A safety discussion from the Mayo Clinic: http://www.mayoclinicproceedings.com/inside.asp?AID=1472&UID=26644
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> SAFETY
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> There have been 3 possible adverse effects of ?-3 FAs: an increase in low-density lipoprotein cholesterol (LDL-C) levels, excess bleeding, and worsening of glycemic control in patients with type 2 diabetes. The increase in LDL-C levels is typically less than 5% to 10%,61 but in patients with severe hypertriglyceridemia, an increase of up to 30% can occur.62 In such cases, however, levels are depressed at baseline and usually do not increase above 130 mg/dL. If this becomes a clinical problem, combination therapy with ?-3 FA and a statin is a safe and effective strategy for patients with elevated levels of both LDL-C and triglycerides.70 At doses of 1 g/d, no effects on LDL-C have been noted. Increased bleeding times have been reported in humans consuming very high quantities (>20 g/d) of ?-3 FAs.71 However, no bleeding complications were reported with 7 g/d of ?-3 FAs in a large restenosis study,30 and the combination of ?-3 FAs with either aspirin or warfarin produced no adverse effects.32 At dosages of 2 to 3 g/d, ?-3 FAs have little effect on bleeding times.72 Some studies have suggested worsening glycemic control in patients with type 2 diabetes when large amounts of fish oil are used.73 However, studies providing more moderate dosages (eg, <3 g/d) have not reported adverse effects.74-77
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> That was the best info I found.
That's it? Just kidding--that is awesome information. Thank you very much...Saturn
poster:saturn
thread:685271
URL: http://www.dr-bob.org/babble/alter/20060817/msgs/686022.html