Posted by qqqsimmons on September 4, 2006, at 19:43:09
In reply to Re: Rutin, Quercetin etc, posted by linkadge on September 4, 2006, at 5:55:30
Hmm, wellnessresources.com claims that quercetin "may help to clear the nerves of a stress chemical known as Substance P, thus helping individuals get a better night’s sleep."
i can get light-headed from quercetin...
i'm not sure what this below study is all about, and what it might mean to quercetin supplementation. any ideas?
Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition.
Medscape Newsletters
Phytother Res. 2002; 16(6):545-9 (ISSN: 0951-418X)
Cyrino LA; Cardoso RC; Hackl LP; Nicolau M
Department of Physiology, CCB, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil.The effects of quercetin on substance P-induced plasma protein extravasation (PE) in the rat dura mater, cerebellum, olfactory bulb and cortex and also its modulation by endopeptidases, angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) were studied. PE was assessed by photometric measurement of extravasated Evans blue. Substance P (SP) and NEP or ACE inhibitors increased the PE in dura mater. Pretreatment with captopril or phosphoramidon potentiated PE induced by SP in the dura mater and cerebellum, respectively. Quercetin increased the PE in the dura mater, cerebellum and cortex. Further results suggested that the PE induced by SP in the dura mater was enhanced by pretreatment with quercetin, similar to that observed with selective peptidase inhibitors. Quercetin-stimulated extravasation in all tissues was abolished by NK-1 receptor blockade. These results suggest that quercetin increases PE in the dura mater and CNS tissues by inhibiting NEP and/or ACE, showing that the effect induced in the dura mater, cerebellum and cortex occurs through endogenous SP accumulation.
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URL: http://www.dr-bob.org/babble/alter/20060817/msgs/683122.html