Posted by KaraS on October 15, 2005, at 22:28:02
In reply to Re: atenolol and Dexedrine trials » KaraS, posted by ed_uk on October 15, 2005, at 15:17:32
> Hi Ed,
>
> How are you doing? Did you increase the doxepin to treat your anxiety? Did you try a higher dose of Dex?
I still haven't increased the Dex yet. I've been working the last couple of weeks and have needed to be sharp (ironic, isn't it?). I don't know how people do drug trials while they're working when you don't know what effect the drugs may have on you (or you do know but you can't afford to be sedated or cognitively dulled).
> >At one point I was thinking desipramine might work but there have been so many people (including yourself) who didn't receive any motivation from desipramine.
>
> I've never taken desipramine, it's not marketed here. I have tried lofepramine though, another noradrenergic TCA.
Yes, I remembered that but was too lazy to look up the name of the drug. I know that it metabolizes to desipramine so you might as well have been taking desipramine, right? And it didn't do a thing for your energy level or to fight your apathy as I remember. Did you try it at any point without an SSRI? If so, did it increase your energy or motivation at all then?
> Perhaps a noradrenergic drug is just what you need. Noradrenergic drugs can increase energy and reduce ADD symptoms. If a dopaminergic drug is not what you need, perhaps a noradrenergic drug will be the answer.
I suppose it can't hurt to try it. I will bring desipramine up with my doctor next time I see him.
> Still, I *definitely* think you should experiment with various doses/regimens of Dexedrine before moving on to a different type of drug.
I agree. I have tried it at lower levels but nothing higher than 5 mg. Maybe a higher dosage would work. It makes sense for that to be the next trial, don't you think? Do you see a problem with higher dosages of Dex along with 25 mg. of doxepin (assuming I'm taking the atenolol of course)?
> >Cymbalta has plenty of effect on NE yet people on it often complain about the apathy.> .....but that's because it's a potent SRI. Desipramine isn't an SRI, it's very different to Cymbalta.
True but you'd think that the NE in Cymbalta would have at least some effect even with all of the SE involved.
> >amitriptyline
>
> What dose did you try? I can take up to 25mg (at night) without side effects. I can't tolerate higher doses.
I think I told you that the first time I tried it was at the 75 mg. level. That was unbelievable. Is it any wonder I go so slowly now considering some of the bad advice I've gotten in the past? But I later tried it at 10 mg. and 25 mg. and still found it to be more sedating than the doxepin at the same levels.
> It would be helpful for you to try a range of different TCAs. Nortriptyline, imipramine etc.ok
Thanks,
K
xx
poster:KaraS
thread:555597
URL: http://www.dr-bob.org/babble/alter/20050924/msgs/567435.html